INT317945

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Context Info
Confidence 0.23
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.59
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Cldn18 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
alcohol 8 85.08 High High
Inflammatory mediators 12 59.84 Quite High
Inflammation 20 54.48 Quite High
cytokine 24 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sepsis 80 98.36 Very High Very High Very High
INFLAMMATION 36 59.84 Quite High
Heart Rate Under Development 8 58.48 Quite High
Adult Respiratory Distress Syndrome 56 5.00 Very Low Very Low Very Low
Injury 16 5.00 Very Low Very Low Very Low
Death 12 5.00 Very Low Very Low Very Low
Hypoxia 8 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 8 5.00 Very Low Very Low Very Low
Respiratory Tract Infection 8 5.00 Very Low Very Low Very Low
Pneumonia 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expression of claudin 4, claudin 18, and occludin was significantly lower, and activation of JNK and ERK signaling pathways was significantly increased in 2CLP monolayers, relative to sham monolayers.
Gene_expression (Expression) of claudin 18
1) Confidence 0.23 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892473 Disease Relevance 0.21 Pain Relevance 0
Inhibition of ERK, not JNK, significantly increased TER and expression of claudin 4 in 2CLP monolayers, and prevented significant differences in claudin 18 expression between 2CLP and sham monolayers.
Gene_expression (expression) of claudin 18
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2892473 Disease Relevance 0.08 Pain Relevance 0
Following isolation and culture of the septic cells, we showed that while phenotype (at day 5) and cell size (at day 2 and 5) of these cells were similar to that of sham or healthy cells, expression of tight junction proteins claudin 4, claudin 18, and occludin were lower and TER was reduced in the septic monolayer.
Gene_expression (expression) of claudin 18
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.30 Pain Relevance 0.17
Claudin 18 expression increased, although not significantly, in U0126 treated, compared to DMSO treated, 2CLP monolayers, and was no longer significantly lower than sham.
Gene_expression (expression) of Claudin 18
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0 Pain Relevance 0

General Comments

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