INT317972

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.83
Pain Relevance 1.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp13) extracellular space (Mmp13) extracellular region (Mmp13)
Golgi apparatus (Mmp13) proteinaceous extracellular matrix (Mmp13) lysosome (Mmp13)
Anatomy Link Frequency
chondrocytes 4
macrophages 1
fibroblasts 1
Mmp13 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 90 98.72 Very High Very High Very High
Osteoarthritis 3 87.16 High High
Inflammation 85 82.72 Quite High
metalloproteinase 48 76.44 Quite High
cytokine 6 71.28 Quite High
Inflammatory response 5 68.96 Quite High
fibrosis 40 60.84 Quite High
ischemia 7 55.64 Quite High
Central nervous system 2 41.16 Quite Low
withdrawal 2 37.88 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 99.66 Very High Very High Very High
Fibrosis 53 99.64 Very High Very High Very High
Rheumatoid Arthritis 90 98.72 Very High Very High Very High
Coronary Heart Disease 32 96.96 Very High Very High Very High
Frailty 6 87.16 High High
Disease 26 83.60 Quite High
INFLAMMATION 88 82.72 Quite High
Apoptosis 9 66.80 Quite High
Cv Unclassified Under Development 4 55.64 Quite High
Coronary Artery Disease 3 53.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Positive_regulation (result) of Transcription (activity) of MMP-13 in chondrocytes associated with targeted disruption and rheumatoid arthritis
1) Confidence 0.41 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.31
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Positive_regulation (upregulated) of Transcription (expression) of MMP-13 associated with fibrosis
2) Confidence 0.23 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Positive_regulation (result) of in fibroblasts Transcription (activity) of MMP-13 in chondrocytes associated with targeted disruption and rheumatoid arthritis
3) Confidence 0.14 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.31
In transgenic mice, excessive MMP-13 activity can result in articular cartilage degradation.25 In RA synovial tissues, MMP-13 is detected in fibroblasts, chondrocytes, macrophages and vascular endothelial cells.26–28 Most importantly, MMP-13 is detected at sites of joint destruction.29 30
Positive_regulation (result) of in macrophages Transcription (activity) of MMP-13 in chondrocytes associated with targeted disruption and rheumatoid arthritis
4) Confidence 0.14 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.81 Pain Relevance 0.31
also stimulated collagenase gene transcription.
Positive_regulation (stimulated) of Transcription (transcription) of collagenase
5) Confidence 0.06 Published 2010 Journal Virol J Section Body Doc Link PMC2976746 Disease Relevance 1.07 Pain Relevance 0.23

General Comments

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