INT317976

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.56
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp8) extracellular space (Mmp8) extracellular region (Mmp8)
proteinaceous extracellular matrix (Mmp8)
Anatomy Link Frequency
livers 1
Mmp8 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory response 10 68.96 Quite High
fibrosis 76 60.84 Quite High
Inflammation 72 50.00 Quite Low
metalloproteinase 54 50.00 Quite Low
cytokine 8 5.00 Very Low Very Low Very Low
Bile 4 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fibrosis 102 99.64 Very High Very High Very High
INFLAMMATION 78 68.60 Quite High
Injury 92 50.00 Quite Low
Cirrhosis 30 50.00 Quite Low
Necrosis 22 5.00 Very Low Very Low Very Low
Poisoning 10 5.00 Very Low Very Low Very Low
Hepatotoxicity 10 5.00 Very Low Very Low Very Low
Liver Disease 8 5.00 Very Low Very Low Very Low
Hepatitis 8 5.00 Very Low Very Low Very Low
Targeted Disruption 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fibrotic animals, hepatic expression of MMP-2, MMP-3, MMP-8, MMP-9 and MMP-13 mRNA were all significantly upregulated, compared to non-fibrotic controls (Figure 6).
Transcription (expression) of MMP-8 associated with fibrosis
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.33 Pain Relevance 0.06
Hepatic transcript levels of MMP-8 (Figure 6C) and MMP-9 (Figure 6D) were 5.6-fold and 6.6-fold increased, respectively, in livers from Marimastat treated animals, whereas hepatic MMP-13 transcripts were 3.0-fold higher in the vehicle treated animals (Figure 6E).
Transcription (transcript) of MMP-8 in livers
2) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892485 Disease Relevance 0.23 Pain Relevance 0.03

General Comments

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