INT3180

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Context Info
Confidence 0.63
First Reported 1978
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 39
Total Number 43
Disease Relevance 25.57
Pain Relevance 10.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PPY)
Anatomy Link Frequency
skin 3
hepatocyte 2
liver 1
sebaceous glands 1
fibroblasts 1
PPY (Homo sapiens)
Pain Link Frequency Relevance Heat
pain pelvic 380 100.00 Very High Very High Very High
Cholecystokinin 17 100.00 Very High Very High Very High
backache 16 100.00 Very High Very High Very High
Chronic pancreatitis 36 99.28 Very High Very High Very High
diabetic neuropathy 5 99.02 Very High Very High Very High
Pain 80 98.74 Very High Very High Very High
Bile 7 98.00 Very High Very High Very High
narcan 5 97.66 Very High Very High Very High
Dismenorea 2 97.20 Very High Very High Very High
epidural 4 96.82 Very High Very High Very High
Disease Link Frequency Relevance Heat
Reprotox - General 3 380 100.00 Very High Very High Very High
Precocious Puberty 76 100.00 Very High Very High Very High
Low Back Pain 16 100.00 Very High Very High Very High
Diabetes Mellitus 10 99.98 Very High Very High Very High
Pancreatic Cancer 5 99.90 Very High Very High Very High
Cancer 243 99.84 Very High Very High Very High
Liver Failure 4 99.84 Very High Very High Very High
Anaemia 8 99.62 Very High Very High Very High
Hypoglycemia 5 99.60 Very High Very High Very High
Porphyria 10 99.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In patients with autonomous diabetic neuropathy insulin induced hypoglycemia leads to subnormal increases of serum PP levels.
Positive_regulation (increases) of PP associated with hypoglycemia and diabetic neuropathy
1) Confidence 0.63 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.64 Pain Relevance 0.19
Therefore, when checking for PP the clinician has to have the patient breathe quietly and regularly, because even normal persons can induce a PP with vigorous respirations.
Positive_regulation (induce) of PP
2) Confidence 0.60 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780608 Disease Relevance 0.35 Pain Relevance 0
Immunohistochemical staining was positive for PP and neuron-specific enolase in all cases and was negative for other peptides except in one specimen with microadenomatosis.
Positive_regulation (positive) of PP in neuron
3) Confidence 0.53 Published 1984 Journal Arch Surg Section Abstract Doc Link 6143548 Disease Relevance 0.98 Pain Relevance 0.08
These data indicate that hepatic PP receptor concentration is upregulated in this model of chronic pancreatitis, most likely due to diminished exposure to ligand.
Positive_regulation (upregulated) of PP receptor associated with chronic pancreatitis
4) Confidence 0.53 Published 1998 Journal J. Surg. Res. Section Abstract Doc Link 9695738 Disease Relevance 0.44 Pain Relevance 0.52
Peak fluorescein serum concentration in patients with CP and steatorrhea (SCP) (n = 6) was < 2.5 micrograms/ml, and CCK and PP responses to the meal were significantly impaired (CCK response = 61 +/- 14 pmol/l/120 min in SCP vs. 110 +/- 14 in controls, P < 0.05; PP response = 3920 +/- 1773 pg/ml/120 min in SCP vs. 13418 +/- 3299 in controls, P < 0.05).
Positive_regulation (responses) of PP in SCP associated with steatorrhea, cholecystokinin and chronic pancreatitis
5) Confidence 0.49 Published 1994 Journal Regul. Pept. Section Abstract Doc Link 8159806 Disease Relevance 0.99 Pain Relevance 0.96
Perception of rectal distension stimuli as well as compliance was independent of intake of food and peptide hormone levels, but CCK and PP levels increased with food, and PP levels decreased with rectal distension.
Positive_regulation (increased) of PP associated with cholecystokinin
6) Confidence 0.45 Published 2009 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18761628 Disease Relevance 0.32 Pain Relevance 0.49
The normal postprandial increase of serum PP levels has been reported to be lacking after vagotomy and reduced in patients with chronic pancreatitis.
Positive_regulation (increase) of PP associated with chronic pancreatitis
7) Confidence 0.45 Published 1978 Journal Z Gastroenterol Section Abstract Doc Link 654388 Disease Relevance 0.10 Pain Relevance 0.10
Intraduodenal infusion of Clinimeal did not result in a significant physiological rise of CCK and PP from the basal values.
Positive_regulation (rise) of PP associated with cholecystokinin
8) Confidence 0.45 Published 1989 Journal Nippon Shokakibyo Gakkai Zasshi Section Abstract Doc Link 2585797 Disease Relevance 0.66 Pain Relevance 0.63
Traditional teaching in medical schools includes the expectation that physicians have the ability to measure PP with a BP cuff as a useful adjunct to physical examination.
Positive_regulation (measure) of PP
9) Confidence 0.43 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780608 Disease Relevance 0.92 Pain Relevance 0
Selective accumulation of PpIX and photodynamic effect after aminolevulinic acid treatment of human adenomyosis xenografts in nude mice.
Positive_regulation (accumulation) of PpIX associated with dismenorea
10) Confidence 0.43 Published 2008 Journal Fertil. Steril. Section Title Doc Link 18462731 Disease Relevance 0.10 Pain Relevance 0.19
Endocrine active pancreatic tumors may cause highly increased PP levels together with other hormones and elevated serum PP levels may be used as a diagnostic indication in such rare cases.
Spec (may) Positive_regulation (cause) of PP associated with pancreatic cancer
11) Confidence 0.42 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.61 Pain Relevance 0.17
In insufficiently treated diabetics elevated basal and postprandial serum levels of PP are found, which return to normal when adequate treatment is administered.
Positive_regulation (elevated) of PP associated with diabetes mellitus
12) Confidence 0.42 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.58 Pain Relevance 0.18
Endocrine active pancreatic tumors may cause highly increased PP levels together with other hormones and elevated serum PP levels may be used as a diagnostic indication in such rare cases.
Positive_regulation (increased) of PP associated with pancreatic cancer
13) Confidence 0.42 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.61 Pain Relevance 0.17
Endocrine active pancreatic tumors may cause highly increased PP levels together with other hormones and elevated serum PP levels may be used as a diagnostic indication in such rare cases.
Positive_regulation (elevated) of PP associated with pancreatic cancer
14) Confidence 0.42 Published 1985 Journal Acta Med. Austriaca Section Abstract Doc Link 3832746 Disease Relevance 0.60 Pain Relevance 0.17
A regional tamponade, as probably initially occurred in the patient of Bandinelli and Lagi, compresses only one or two chambers, may limit cardiac output, but is too confined to cause the heart chamber to compete for space and to generate a PP.
Positive_regulation (generate) of PP in heart chamber associated with cv unclassified under development
15) Confidence 0.40 Published 2007 Journal Intern Emerg Med Section Body Doc Link PMC2780608 Disease Relevance 1.07 Pain Relevance 0
Competitive binding studies were performed by incubating hepatocyte microsomal preparation with 125I-labeled PP (20-40 pM) and increasing concentrations of nonlabeled PP (1 x 10(-10) to 1 x 10(-6) M).
Positive_regulation (increasing) of PP in hepatocyte
16) Confidence 0.31 Published 1998 Journal J. Surg. Res. Section Abstract Doc Link 9695738 Disease Relevance 0.30 Pain Relevance 0.30
In humans, it is responsible for painful skin photosensitivity and, occasionally, liver failure due to accumulation of PP in the liver.
Positive_regulation (accumulation) of PP in liver associated with liver failure, pain and sunburn
17) Confidence 0.23 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15677551 Disease Relevance 1.22 Pain Relevance 0.12
Compared with BALB/cByJCrl, C57BL/6JCrl mice developed moderate but increasing anemia and intense liver accumulation of PP with severe hepatocyte damage and loss.
Positive_regulation (accumulation) of PP in hepatocyte associated with anaemia
18) Confidence 0.23 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15677551 Disease Relevance 1.45 Pain Relevance 0.12
The average increase in PpIX fluorescence in human skin was 18% +/- 6% and 43% +/- 10% for ALA combined with 80 nmol/L SF and 120 nmol/L SF, respectively.
Positive_regulation (increase) of PpIX in skin
19) Confidence 0.20 Published 2008 Journal Transl Res Section Abstract Doc Link 18774542 Disease Relevance 0.77 Pain Relevance 0.10
It was also hypothesised that the previous 'low prevalence' of PP among pregnant women could be attributed to a previous lack of a label for the condition, implying that the medical profession had simply not discovered an existing condition.


Positive_regulation (attributed) of PP associated with pain pelvic
20) Confidence 0.15 Published 2010 Journal BMC Public Health Section Body Doc Link PMC2964625 Disease Relevance 0.92 Pain Relevance 0.86

General Comments

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