INT31804

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Context Info
Confidence 0.40
First Reported 1988
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.92
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Asprv1)
Anatomy Link Frequency
skin 2
Asprv1 (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 8 98.80 Very High Very High Very High
visual analogue scale 1 98.36 Very High Very High Very High
anesthesia 8 97.44 Very High Very High Very High
cINOD 2 89.56 High High
Inflammation 1 89.08 High High
methotrexate 1 83.52 Quite High
Arthritis 4 75.00 Quite High
spinal inflammation 1 54.92 Quite High
Pain 3 25.00 Low Low
nociceptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Nociception 12 99.82 Very High Very High Very High
Rheumatoid Arthritis 8 98.80 Very High Very High Very High
Diarrhoea 1 97.72 Very High Very High Very High
Disease 1 95.00 High High
INFLAMMATION 2 89.08 High High
Toxicity 2 76.20 Quite High
Arthritis 3 75.00 Quite High
Seronegative Spondarthritis 1 75.00 Quite High
Low Back Pain 1 54.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This implied requirement of the intact parent molecule (SASP) to produce this effect, at these concentrations.
Positive_regulation (requirement) of SASP
1) Confidence 0.40 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 2902897 Disease Relevance 0.09 Pain Relevance 0.13
It was concluded that SASP appears to be effective and safe in the treatment of JRA and JSA patients.
Positive_regulation (effective) of SASP associated with rheumatoid arthritis
2) Confidence 0.19 Published 1998 Journal Clin. Rheumatol. Section Abstract Doc Link 9805178 Disease Relevance 0.96 Pain Relevance 0.54
SASP is effective in PSA but the partial clinical response to placebo indicates the importance of placebo-controlled studies in this variable disease.
Positive_regulation (effective) of SASP associated with disease
3) Confidence 0.09 Published 1993 Journal Br. J. Rheumatol. Section Abstract Doc Link 8104656 Disease Relevance 0.25 Pain Relevance 0.09
The studies demonstrated significant correlations of (1) the current intensity which induces the skin vasomotor reflex (SVmR) vs. the magnitude of the SVmR under the three different anesthesia depths, (2) the anesthesia depth vs. the magnitude of the SVmR (inverse proportion) under the same current intensity and (3) the duration of electrostimulation vs. the magnitude of the SVmR.
Positive_regulation (induces) of skin vasomotor reflex in skin associated with anesthesia
4) Confidence 0.00 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9760055 Disease Relevance 0.27 Pain Relevance 0.34
Because nociceptive stimuli induce the skin vasomotor reflex (SVmR), the assessment of the SVmR would be a useful indicator to represent nociception.
Positive_regulation (induce) of skin vasomotor reflex in skin associated with nociception
5) Confidence 0.00 Published 1998 Journal J. Auton. Nerv. Syst. Section Abstract Doc Link 9760055 Disease Relevance 0.36 Pain Relevance 0.15

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