INT31805

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Context Info
Confidence 0.73
First Reported 1988
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.23
Pain Relevance 1.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nuclear envelope (LBR) small molecule metabolic process (LBR) nucleus (LBR)
DNA binding (LBR)
Anatomy Link Frequency
lymphocytes 1
spleen 1
LBR (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 108 99.98 Very High Very High Very High
Inflammation 119 92.76 High High
Inflammatory stimuli 10 90.88 High High
tolerance 5 84.56 Quite High
Crohn's disease 4 82.48 Quite High
cINOD 1 67.28 Quite High
Inflammatory response 6 56.44 Quite High
Inflammatory mediators 4 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 135 92.76 High High
Targeted Disruption 2 87.20 High High
Disease 11 81.84 Quite High
Inflammatory Bowel Disease 6 68.64 Quite High
Infection 4 26.24 Quite Low
Insulin Resistance 2 21.60 Low Low
Cancer 25 9.20 Low Low
Sprains And Strains 12 8.24 Low Low
Obesity 7 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of sulphasalazine (SASP), sulphapyridine (SP), and 5-aminosalicylic acid (5-ASA) have been studied on mouse spleen cells cultured in the presence of phytohaemagglutinin (PHA), concanavalin A (Con A), pokeweed mitogen (PWM) and lipopolysaccharide (LPS).
Localization (cultured) of PHA in spleen
1) Confidence 0.73 Published 1988 Journal Br. J. Rheumatol. Section Abstract Doc Link 2902897 Disease Relevance 0.07 Pain Relevance 0.10
To understand the differences observed in the extent of immune-suppression caused by BMMSCs and WJMSCs, we probed into the cytokine secretion profiles of PHA-activated lymphocytes in co-cultures with either primed or unprimed MSCs.
Localization (secretion) of PHA in lymphocytes associated with cytokine
2) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.38 Pain Relevance 0.41
The IL-6 induction by both MTB (p < 0.003) and CW (p < 0.002) in the presence of PHA was found to be highly statistically significant.
Localization (presence) of PHA
3) Confidence 0.08 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0 Pain Relevance 0.03
In the presence of the mitogens PHA or PWM, only MTB treatment produced an increase in IL-10 above baseline.
Localization (presence) of PHA
4) Confidence 0.07 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.79 Pain Relevance 0.59

General Comments

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