INT31809

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Context Info
Confidence 0.75
First Reported 1988
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.30
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR2B) cytoplasm (HTR2B) signal transducer activity (HTR2B)
Anatomy Link Frequency
blood 1
endothelial cells 1
heart valves 1
HTR2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Migraine 13 99.86 Very High Very High Very High
Serotonin 3 99.04 Very High Very High Very High
Clonidine 10 97.28 Very High Very High Very High
headache 4 93.24 High High
ergotamine 1 91.96 High High
fifth nerve 1 90.36 High High
agonist 10 87.96 High High
Dopamine 4 87.68 High High
Potency 5 71.16 Quite High
Disease Link Frequency Relevance Heat
Headache 7 99.86 Very High Very High Very High
Fibrosis 2 99.66 Very High Very High Very High
Sleep Disorders 5 93.96 High High
Syndrome 1 88.36 High High
Migraine Disorders 7 88.24 High High
Carcinoid 1 88.00 High High
Coronary Heart Disease 2 85.28 High High
Hypotension 7 84.88 Quite High
Disease 2 80.08 Quite High
Heart Disease 1 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In these cases, the pathogenesis is suspected to involve serotonin-mediated abnormal fibrogenesis by means of the 5-HT2B receptors, which are expressed in the fibroblasts of heart valves.
Gene_expression (expressed) of 5-HT2B in heart valves associated with fibrosis and serotonin
1) Confidence 0.75 Published 2004 Journal Mov. Disord. Section Abstract Doc Link 15197703 Disease Relevance 0.89 Pain Relevance 0.43
All tissues expressed 5-HT1Dbeta, 5-HT2A, 5-HT2B, 5-HT4 and 5-HT7 mRNAs.
Gene_expression (expressed) of 5-HT2B
2) Confidence 0.65 Published 1996 Journal Eur. J. Neurosci. Section Abstract Doc Link 8743744 Disease Relevance 0.44 Pain Relevance 0.94
The inducible 1C11 cell line has the unique property of acquiring within 4 days a complete serotonergic phenotype (1C11* cells), including three 5-HT receptors. 5-HT1B/1D and 5-HT2B receptors are expressed since day 2 of the serotonergic differentiation while 5-HT2A receptors are induced at day 4.
Gene_expression (expressed) of 5-HT2B
3) Confidence 0.65 Published 1998 Journal J. Biol. Chem. Section Abstract Doc Link 9651340 Disease Relevance 0 Pain Relevance 0
The key findings are that nitric oxide is an important trigger for migraine, that 5-HT2B/5-HT2C receptors are present on endothelial cells and trigger nitric oxide release when activated and that supersensitivity of the 5-HT2B/5-HT2C receptor is a neurochemical feature predisposing to headache.
Gene_expression (present) of 5-HT2B in endothelial cells associated with migraine and headache
4) Confidence 0.29 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7824037 Disease Relevance 0.36 Pain Relevance 0.44
B-HT920 was found to produce a dose-response profile qualitatively similar to, but weaker than, clonidine: low doses impaired memory and began to lower blood pressure and produce sedation, while high doses improved memory.
Gene_expression (produce) of B-HT920 in blood associated with sleep disorders and clonidine
5) Confidence 0.08 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2903226 Disease Relevance 0.60 Pain Relevance 0.64

General Comments

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