INT31810

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Context Info
Confidence 0.47
First Reported 1988
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.75
Pain Relevance 4.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (HTR2B) cytoplasm (HTR2B) signal transducer activity (HTR2B)
Anatomy Link Frequency
brain 1
HTR2B (Homo sapiens)
Pain Link Frequency Relevance Heat
Clonidine 30 100.00 Very High Very High Very High
Serotonin 12 100.00 Very High Very High Very High
5HT 10 100.00 Very High Very High Very High
Dopamine 5 100.00 Very High Very High Very High
antagonist 6 99.88 Very High Very High Very High
Potency 11 97.80 Very High Very High Very High
antidepressant 42 95.36 Very High Very High Very High
depression 45 90.92 High High
agonist 27 90.48 High High
Sumatriptan 1 88.24 High High
Disease Link Frequency Relevance Heat
Schizophrenia 13 96.68 Very High Very High Very High
Hypotension 21 95.52 Very High Very High Very High
Anxiety Disorder 15 94.40 High High
Depression 47 90.92 High High
Cognitive Disorder 5 84.68 Quite High
Sleep Disorders 24 80.72 Quite High
Psychosis 7 75.00 Quite High
Urological Neuroanatomy 1 65.28 Quite High
Disease 1 50.00 Quite Low
Affective Disorder 3 34.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The inhibitory potency of the drugs was significantly correlated with their affinity for 5-HTID receptors in human brain and for cloned human 5-HT1D alpha and 5-HT1D beta receptors, but not with their affinity for 5-HT1B, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, 5-HT5A, 5-HT5B and 5-HT7 receptors.
5-HT2B Neg (not) Binding (affinity) of in brain associated with potency
1) Confidence 0.47 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8692281 Disease Relevance 0 Pain Relevance 0.48
PHARMACOLOGICAL PROPERTIES: Aripiprazole is a quinolinone derivative with a high affinity for dopamine D2 and D3 receptors, and serotonin 5-HT1A, 5-HT2A and 5-HT2B receptors.
5-HT2B Binding (affinity) of associated with dopamine and serotonin
2) Confidence 0.36 Published 2004 Journal Drugs Section Abstract Doc Link 15257633 Disease Relevance 0.54 Pain Relevance 0.34
These differences in rank order potency are consistent with the recent proposal of alpha-2 receptor subtypes, a rauwolscine-sensitive site (Rs) that binds clonidine greater than B-HT920 greater than guanfacine and a rauwolscine-insensitive site (Ri) that binds guanfacine greater than clonidine greater than B-HT920 (Boyajian and Leslie, 1987).
B-HT920 Binding (binds) of associated with clonidine and potency
3) Confidence 0.05 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2903226 Disease Relevance 0.59 Pain Relevance 0.92
These differences in rank order potency are consistent with the recent proposal of alpha-2 receptor subtypes, a rauwolscine-sensitive site (Rs) that binds clonidine greater than B-HT920 greater than guanfacine and a rauwolscine-insensitive site (Ri) that binds guanfacine greater than clonidine greater than B-HT920 (Boyajian and Leslie, 1987).
B-HT920 Binding (binds) of associated with clonidine and potency
4) Confidence 0.05 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2903226 Disease Relevance 0.61 Pain Relevance 0.94
These differences in rank order potency are consistent with the recent proposal of alpha-2 receptor subtypes, a rauwolscine-sensitive site (Rs) that binds clonidine greater than B-HT920 greater than guanfacine and a rauwolscine-insensitive site (Ri) that binds guanfacine greater than clonidine greater than B-HT920 (Boyajian and Leslie, 1987).
B-HT920 Binding (binds) of associated with clonidine and potency
5) Confidence 0.05 Published 1988 Journal J. Neurosci. Section Abstract Doc Link 2903226 Disease Relevance 0.60 Pain Relevance 0.94
Agomelatine also is a serotonin-receptor antagonist that binds to and inhibits the activity of serotonin 5HT-2C receptor subtypes, but it does not bind to other serotonin receptor subtypes. 5HT-2C receptor antagonism is associated with antidepressant and anti-anxiety activity and also increases slow-wave sleep (which is abnormally diminished in depression).35 Agomelatine does not directly affect the uptake of serotonin, norepinephrine, or dopamine.
5HT-2C receptor Binding (binds) of associated with dopamine, antidepressant, depression, antagonist, anxiety disorder, 5ht and serotonin
6) Confidence 0.03 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2785860 Disease Relevance 0.41 Pain Relevance 0.73

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