INT318122

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Context Info
Confidence 0.80
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.83
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (AGR2) extracellular region (AGR2) endoplasmic reticulum (AGR2)
Anatomy Link Frequency
epithelial cells 1
pancreatic duct 1
AGR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 40 94.60 High High
imagery 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 376 100.00 Very High Very High Very High
Cancer 176 98.64 Very High Very High Very High
Adenocarcinoma 24 97.04 Very High Very High Very High
Pancreatitis 96 94.60 High High
Disease 64 89.44 High High
Ovarian Cancer 8 70.36 Quite High
Malignant Neoplastic Disease 80 67.84 Quite High
Death 8 32.32 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Along with these previous studies, it is evidenced that AGR2 is likely to be secreted into the pancreatic duct fluid early in pancreatic cancer progression.
Localization (secreted) of AGR2 in pancreatic duct associated with pancreatic cancer
1) Confidence 0.80 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.70 Pain Relevance 0
A recent study using IHC showed that AGR2 was highly expressed in both PanINs and pancreatic cancer tissues and is secreted into the culture media of pancreatic cancer cell lines [11].
Localization (secreted) of AGR2 associated with pancreatic cancer
2) Confidence 0.80 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.29 Pain Relevance 0
The same study also demonstrated that AGR2 was secreted into culture media by pancreatic cancer cells.
Localization (secreted) of AGR2 associated with pancreatic cancer
3) Confidence 0.80 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.88 Pain Relevance 0.07
The discovery of AGR2 elevation in the pancreatic juice of PanIN3 patients in this study may provide a future opportunity to develop and test this candidate as juice biomarker for PanIN3.
Localization (elevation) of AGR2
4) Confidence 0.75 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.92 Pain Relevance 0.09
However, a recent study found that AGR2 is localized to the endoplasmic reticulum in intestinal epithelial cells and did not detect AGR2 in secretory granules or in the intestinal lumen[28].
Localization (localized) of AGR2 in epithelial cells
5) Confidence 0.75 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.58 Pain Relevance 0
Taken together, these data confirm that mAb AGR2.43 is specific to AGR2 and can be used for multiple applications.


Localization (specific) of AGR2
6) Confidence 0.75 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.15 Pain Relevance 0
Thus it is possible that only a fraction of AGR2 is actually secreted.
Localization (secreted) of AGR2
7) Confidence 0.71 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.64 Pain Relevance 0
The mechanism governing AGR2 secretion is currently unknown.
Localization (secretion) of AGR2
8) Confidence 0.70 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2893103 Disease Relevance 0.67 Pain Relevance 0

General Comments

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