INT318136

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.65
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (HBB) transport (HBB)
HBB (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 8 49.28 Quite Low
Spinal cord 2 28.76 Quite Low
fibrosis 10 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
Parenteral administration 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 374 99.84 Very High Very High Very High
Anaemia 50 91.20 High High
Thrombocytopenia 6 89.00 High High
Calcification 2 84.56 Quite High
Disease 28 83.76 Quite High
Mixed Connective Tissue Disorder 2 79.96 Quite High
Hypertension 4 74.80 Quite High
Intrauterine Growth Retardation 2 67.72 Quite High
Diabetes Mellitus 20 56.32 Quite High
Hypothyroidism 16 55.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The beta globin gene mutations cause a reduced or absent production of beta globin chains.
Positive_regulation (cause) of Neg (absent) Gene_expression (production) of beta globin
1) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.16 Pain Relevance 0
In contrast with the classical recessive forms of beta-thalassemia, which lead to a reduced production of normal beta globin chains, some rare mutations result in the synthesis of extremely unstable beta globin variants which precipitate in erythroid precursors causing ineffective erythropoiesis.
Positive_regulation (lead) of Gene_expression (production) of beta globin associated with thalassemia
2) Confidence 0.04 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2893117 Disease Relevance 1.49 Pain Relevance 0

General Comments

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