INT318185

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.86
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MUC5AC, MMP3) peptidase activity (MMP3) extracellular space (MMP3)
proteinaceous extracellular matrix (MMP3) cell adhesion (MUC5AC) nucleus (MMP3)
MUC5AC (Homo sapiens)
MMP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 20 100.00 Very High Very High Very High
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 28 100.00 Very High Very High Very High
Adhesions 11 99.38 Very High Very High Very High
Cancer 27 94.52 High High
Pancreatic Ductal Carcinoma 5 68.88 Quite High
Carcinoma In Situ 1 42.48 Quite Low
Ductal Carcinoma 1 40.88 Quite Low
Metastasis 14 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 2 5.00 Very Low Very Low Very Low
Hyperplasia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Knockdown of MUC5AC reduced the ability of pancreatic cancer cells to adhesion and invasion, suggesting that MUC5AC might contribute to the invasive motility of pancreatic cancer cells by enhancing the expression of integrins, MMP-3, VEGF and activating Erk pathway.



MUC5AC Positive_regulation (enhancing) of Gene_expression (expression) of MMP-3 associated with pancreatic cancer, metalloproteinase and adhesions
1) Confidence 0.09 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2893453 Disease Relevance 0.86 Pain Relevance 0.13

General Comments

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