INT318233

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 17
Disease Relevance 4.37
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
Anatomy Link Frequency
nucleus 2
cardiovascular system 1
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 17 90.32 High High
Glutamate 5 27.20 Quite Low
alcohol 15 5.00 Very Low Very Low Very Low
Analgesic 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Glioma 312 98.40 Very High Very High Very High
Cancer 420 95.04 Very High Very High Very High
Stress 50 90.60 High High
INFLAMMATION 17 90.08 High High
Lung Cancer 12 89.84 High High
Shock 5 88.36 High High
Apoptosis 263 86.64 High High
Aging 10 86.36 High High
Necrosis 5 85.60 High High
Metastasis 24 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SIRT1 increased FOXO3A ability to induce cell cycle arrest and enhanced expression of a FOXO3A target involved in DNA repair, such as GADD45 [24].
Gene_expression (expression) of FOXO3A
1) Confidence 0.60 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.51 Pain Relevance 0
In addition, Northern blot analysis showed that RNA levels of the SIRT1-dependent transcription factor FOXO3A and its target GADD45 were increased in the studied group after marathon (Figure 7).
Gene_expression (levels) of FOXO3A
2) Confidence 0.53 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.12 Pain Relevance 0
Because it is known that exercise training exerts its beneficial effects particularly on the cardiovascular system, we tested FOXO3A and its targets involvement in group, showing that exercise training enhanced FOXO3A RNA levels.
Gene_expression (levels) of FOXO3A in cardiovascular system
3) Confidence 0.53 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.49 Pain Relevance 0
Strenuous physical load significantly increased HSP70, HSP32, Mn-SOD, Cu-Zn SOD, iNOS, GADD45, bcl-2, forkhead box O (FOXO3A) and SIRT1 expression after the marathon, while decreasing bax, SIRT3 and SIRT4 expression (P < 0.0001).


Gene_expression (expression) of forkhead box O
4) Confidence 0.53 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.38 Pain Relevance 0
Strenuous physical load significantly increased HSP70, HSP32, Mn-SOD, Cu-Zn SOD, iNOS, GADD45, bcl-2, forkhead box O (FOXO3A) and SIRT1 expression after the marathon, while decreasing bax, SIRT3 and SIRT4 expression (P < 0.0001).


Gene_expression (expression) of FOXO3A
5) Confidence 0.53 Published 2010 Journal BMC Physiol Section Abstract Doc Link PMC2893521 Disease Relevance 0.38 Pain Relevance 0
Thus, increased activity of the p27 promoter expressed as luciferase expression with the promoter constructs indicate that the regulation of p27Kip1 protein levels by cathepsin B and uPAR could be, at least partially, explained by the regulation of its promoter activity by increased expression of FOXO3a.
Gene_expression (expression) of FOXO3a
6) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.33 Pain Relevance 0
Moreover, a direct correlation between the low expression of p27Kip1 and FOXO3a and higher expression of Ki67 with the malignant glioma has been reported [23].
Gene_expression (expression) of FOXO3a associated with glioma
7) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 1.00 Pain Relevance 0
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
Gene_expression (expression) of FOXO3a
8) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.34 Pain Relevance 0.09
In the present study, FOXO3a expression was positively correlated with p27kip1 expression (Fig. 2A) but inversely associated with cell proliferation as identified by Ki67 (Fig. 3A), which is a marker of cell proliferation expressed specifically in the cell nucleus from late G1 to S phase.
Gene_expression (expression) of FOXO3a in nucleus
9) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.20 Pain Relevance 0
Western blotting revealed decreased expression of p-AKT, which is an indicator of PI3K kinase activity, and increased expression of FOXO3a and p27Kip1 in the nuclear extracts (Fig. 4B).
Gene_expression (expression) of FOXO3a
10) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
These results indicate that the knockdown of cathespin B and uPAR in SNB19 and U251 cells induced G0/G1 arrest with the increased expression of p27Kip1 and FOXO3a and reduced PI3K activity.
Gene_expression (expression) of FOXO3a
11) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
For FOXO proteins to be active, newly synthesized FOXO3a must translocate to the nucleus, which is further influenced by its phosphorylation status.
Gene_expression (synthesized) of FOXO3a in nucleus
12) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
The expression of p27Kip1 and FOXO3a proteins were also assessed in cathepsin B and uPAR-overexpressing cells, and we found a correlation with the above mentioned results (Fig.
Gene_expression (expression) of FOXO3a
13) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
These results were further confirmed with the increased expression of p27Kip1 and FOXO3a when treated with Ly294002 (10 ┬ÁM) and increased luciferase expression with the siRNA and Ly294002 treatments when the FOXO binding promoter region of p27Kip1 was used.
Gene_expression (expression) of FOXO3a
14) Confidence 0.32 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2908539 Disease Relevance 0.35 Pain Relevance 0
This increased expression of p27Kip1 correlates with decreased expression of p-PI3K, p-AKT, cyclin E, cyclin D1, cyclin D2 and increased expression of FOXO3a protein.
Gene_expression (expression) of FOXO3a
15) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.28 Pain Relevance 0
We found that the nuclear fractions of treated cells expressed more FOXO3a protein than the controls (Fig.
Gene_expression (expressed) of FOXO3a
16) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Immunoblot analysis revealed that the expression of FOXO3a increased with the treatments, especially with pCU treatment (Fig. 4A); the treatments did not affect the other FOXO forms significantly (Fig.
Gene_expression (expression) of FOXO3a
17) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0

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