INT318235

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Context Info
Confidence 0.54
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 9
Disease Relevance 2.59
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
Anatomy Link Frequency
cardiovascular system 2
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 91.04 High High
Glutamate 3 27.20 Quite Low
alcohol 9 5.00 Very Low Very Low Very Low
Analgesic 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 30 92.12 High High
INFLAMMATION 9 90.80 High High
Aging 6 87.88 High High
Apoptosis 147 86.64 High High
Necrosis 3 85.60 High High
Cancer 210 78.88 Quite High
Leukemia 6 56.72 Quite High
Glioma 156 50.00 Quite Low
Fever 3 22.20 Low Low
Lifespan 3 8.40 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SIRT1 increased FOXO3A ability to induce cell cycle arrest and enhanced expression of a FOXO3A target involved in DNA repair, such as GADD45 [24].
Positive_regulation (enhanced) of Gene_expression (expression) of FOXO3A
1) Confidence 0.54 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.51 Pain Relevance 0
Because it is known that exercise training exerts its beneficial effects particularly on the cardiovascular system, we tested FOXO3A and its targets involvement in group, showing that exercise training enhanced FOXO3A RNA levels.
Positive_regulation (enhanced) of Gene_expression (levels) of FOXO3A in cardiovascular system
2) Confidence 0.41 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.49 Pain Relevance 0
SIRT1 increased FOXO3A ability to induce cell cycle arrest and enhanced expression of a FOXO3A target involved in DNA repair, such as GADD45 [24].
Positive_regulation (induce) of Gene_expression (expression) of FOXO3A
3) Confidence 0.39 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.52 Pain Relevance 0
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
Positive_regulation (increased) of Gene_expression (expression) of FOXO3a
4) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.34 Pain Relevance 0.09
Thus, increased activity of the p27 promoter expressed as luciferase expression with the promoter constructs indicate that the regulation of p27Kip1 protein levels by cathepsin B and uPAR could be, at least partially, explained by the regulation of its promoter activity by increased expression of FOXO3a.
Positive_regulation (increased) of Gene_expression (expression) of FOXO3a
5) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.33 Pain Relevance 0
Western blotting revealed decreased expression of p-AKT, which is an indicator of PI3K kinase activity, and increased expression of FOXO3a and p27Kip1 in the nuclear extracts (Fig. 4B).
Positive_regulation (increased) of Gene_expression (expression) of FOXO3a
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
These results indicate that the knockdown of cathespin B and uPAR in SNB19 and U251 cells induced G0/G1 arrest with the increased expression of p27Kip1 and FOXO3a and reduced PI3K activity.
Positive_regulation (increased) of Gene_expression (expression) of FOXO3a
7) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Thus, these findings invite the conclusion that the increased p27Kip1 expression with the treatments is due to the increased nuclear expression of FOXO3a, which binds to the -2984 bp region on the p27Kip1 promoter and could be mediated by the low expression of p-AKT.
Positive_regulation (mediated) of Gene_expression (expression) of FOXO3a
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.41 Pain Relevance 0.09
Immunoblot analysis revealed that the expression of FOXO3a increased with the treatments, especially with pCU treatment (Fig. 4A); the treatments did not affect the other FOXO forms significantly (Fig.
Positive_regulation (increased) of Gene_expression (expression) of FOXO3a
9) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0

General Comments

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