INT318253

Context Info Confidence 0.09 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 6 Disease Relevance 0 Pain Relevance 1.04

YTHDF2 (Homo sapiens)

Pain Link Frequency Relevance Heat Oxycodone 156 99.22 methadone 78 89.84 Opioid 18 50.00 antidepressant 6 5.00

Disease Link Frequency Relevance Heat Reflex Sympathetic Dystrophy 18 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Concentrations of Pharmaceuticals Downstream of NY1, NY2, and NY3 Effluents

Gene_expression (Concentrations) of NY2

1) Confidence 0.09 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0.13

Over half of the stream samples collected below the NY2 discharge had two or more pharmaceuticals with concentrations greater than 1 ?

Gene_expression (discharge) of NY2

2) Confidence 0.08 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0.11

Median total pharmaceutical concentrations in samples of NY2 and NY3 effluents were generally 30 to almost 500 times higher than total pharmaceutical concentrations typically found in the national effluent survey.

Gene_expression (effluents) of NY2

3) Confidence 0.08 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0

g/L; median concentrations for the four pharmaceuticals (butalbital, carisoprodol, diazepam, and oxycodone) most commonly detected in samples of NY2 effluent ranged from 0.74 to 11 ?

Gene_expression (effluent) of NY2 associated with oxycodone

4) Confidence 0.08 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0.52

However, 36% (84 of 236) of the individual pharmaceutical concentrations in samples of NY2 effluent and 61% (155 of 254) of the individual pharmaceutical concentrations in samples of NY3 effluent exceeded 1 ?

Gene_expression (effluent) of NY2

5) Confidence 0.08 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0.29

By contrast, the median total pharmaceutical concentration in samples from NY2 effluent (26 ?

Gene_expression (effluent) of NY2

6) Confidence 0.08 Published 2010 Journal Environmental Science & Technology Section Body Doc Link PMC2893609 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.