INT318271

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 2.74
Pain Relevance 3.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (SLC32A1) plasma membrane (SLC32A1) transmembrane transport (SLC32A1)
Anatomy Link Frequency
epithelium 2
SLC32A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 334 100.00 Very High Very High Very High
Cannabinoid receptor 84 100.00 Very High Very High Very High
GABAergic 506 98.68 Very High Very High Very High
Central nervous system 6 97.60 Very High Very High Very High
agonist 4 71.36 Quite High
Nicotine 18 5.00 Very Low Very Low Very Low
fluoxetine 12 5.00 Very Low Very Low Very Low
Pyramidal cell 12 5.00 Very Low Very Low Very Low
Glutamate 10 5.00 Very Low Very Low Very Low
Neurotransmitter 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Lifespan 162 99.44 Very High Very High Very High
Nicotine Addiction 136 93.16 High High
Aging 102 78.04 Quite High
Stress 4 62.72 Quite High
Anxiety Disorder 6 57.00 Quite High
Generalized Anxiety Disorder 16 37.20 Quite Low
Amblyopia 42 5.00 Very Low Very Low Very Low
Asthma 8 5.00 Very Low Very Low Very Low
Cataract 6 5.00 Very Low Very Low Very Low
Cognitive Disorder 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We quantified the inhibitory modulating cannabinoid receptor (CB1), GABA vesicular transporter (VGAT), GABA synthesizing enzymes (GAD65/GAD67), GABAA receptor anchoring protein (Gephyrin), and GABAA receptor subunits (GABAA?
Gene_expression (synthesizing) of VGAT associated with gaba and cannabinoid receptor
1) Confidence 0.44 Published 2010 Journal Frontiers in Cellular Neuroscience Section Abstract Doc Link PMC2893712 Disease Relevance 0.29 Pain Relevance 0.39
To quantify changes in the balance between the mechanisms that produce and traffic GABA in the pre-synaptic terminal, we calculated an index of GAD65:VGAT expression.
Gene_expression (expression) of VGAT associated with gaba
2) Confidence 0.44 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.43 Pain Relevance 0.36
To further examine how the pre-synaptic components of the GABAergic system change across the lifespan in human V1, we quantified the expression of two key inhibitory proteins, CB1 and VGAT (Figure 2).
Gene_expression (expression) of VGAT associated with cannabinoid receptor, lifespan and gabaergic
3) Confidence 0.44 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.48 Pain Relevance 0.51
VGAT expression was highest in infants (<1 year) and pre-teens (5–11 years), and had about 32% less expression in adults (21–55 years; p <?
Gene_expression (expression) of VGAT
4) Confidence 0.44 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.45 Pain Relevance 0.37
In the second stage, the teenage transition was a switch from a greater capacity for trafficking GABA (more VGAT) to a greater capacity to produce the on-demand pool of GABA (more GAD65).
Gene_expression (produce) of VGAT associated with gaba
5) Confidence 0.42 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.06 Pain Relevance 0.17
Interestingly, in the human airway epithelium there is no VGAT expression, suggesting GABA is released from airway epithelial cells in a vesicle independent fashion [18].
Gene_expression (expression) of VGAT in epithelium associated with gaba
6) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.13 Pain Relevance 0.61
In regard to transporters, there was no GAT-3 and VGAT expression in human large and small airway epithelium.
Gene_expression (expression) of VGAT in epithelium
7) Confidence 0.41 Published 2010 Journal Respir Res Section Body Doc Link PMC2988726 Disease Relevance 0.42 Pain Relevance 0.56
There was more VGAT expression in both young children (<11 years) and older adults (>55 years; Figure 3).
Gene_expression (expression) of VGAT
8) Confidence 0.38 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2893712 Disease Relevance 0.48 Pain Relevance 0.31

General Comments

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