INT318298

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CD28) cell differentiation (MECOM) plasma membrane (CD28)
nucleus (MECOM) intracellular (MECOM) DNA binding (MECOM)
Anatomy Link Frequency
T-cell 2
MECOM (Homo sapiens)
CD28 (Homo sapiens)
Pain Link Frequency Relevance Heat
abatacept 1 99.92 Very High Very High Very High
rheumatoid arthritis 4 90.28 High High
cytokine 4 64.84 Quite High
methotrexate 16 5.00 Very Low Very Low Very Low
Infliximab 6 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
Etanercept 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Leflunomide 4 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 42 99.40 Very High Very High Very High
Vasculitis 60 98.44 Very High Very High Very High
Rheumatoid Arthritis 4 90.28 High High
Systemic Lupus Erythematosus 7 89.28 High High
Urological Neuroanatomy 17 83.12 Quite High
Glomerulonephritis 10 74.16 Quite High
Paroxysmal Nocturnal Hemoglobinuria 1 66.96 Quite High
Autoimmune Disease 8 58.36 Quite High
Syndrome 4 42.96 Quite Low
Eosinophilia 2 39.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Abatacept, a fusion protein of CTLA4-Ig which selectively modulates T-cell co-stimulation by blocking the engagement of CD28, would theoretically be of benefit in AAV, although the EUVAS ABAVAS trial was terminated early due to slow recruitment.
fusion protein Negative_regulation (blocking) of CD28 Binding (engagement) of in T-cell associated with abatacept and vasculitis
1) Confidence 0.00 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893757 Disease Relevance 1.08 Pain Relevance 0.18

General Comments

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