INT3183

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Context Info
Confidence 0.41
First Reported 1978
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 15
Disease Relevance 6.56
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
muscle 2
plasma 1
forearm 1
sympathetic 1
MRXS5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 11 99.56 Very High Very High Very High
adenocard 15 98.92 Very High Very High Very High
acular 5 98.64 Very High Very High Very High
Pain 3 97.24 Very High Very High Very High
noradrenaline 5 96.32 Very High Very High Very High
agonist 12 96.20 Very High Very High Very High
Clonidine 10 95.44 Very High Very High Very High
Dismenorea 4 95.16 Very High Very High Very High
abdominal pain 1 92.36 High High
Onset of action 1 92.12 High High
Disease Link Frequency Relevance Heat
Ocular Hypertension 64 99.84 Very High Very High Very High
Reprotox - General 1 19 99.84 Very High Very High Very High
Injury 10 99.82 Very High Very High Very High
INFLAMMATION 18 99.56 Very High Very High Very High
Increased Venous Pressure Under Development 25 99.08 Very High Very High Very High
Glaucoma 34 98.80 Very High Very High Very High
Pain 2 97.24 Very High Very High Very High
Uveitis 4 95.20 Very High Very High Very High
Low Back Pain 6 92.84 High High
Abdominal Pain 1 92.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A major drawback of the current therapeutic strategies aiming at controlling PGs is that they aim at early steps of biosynthesis thus blocking all PGs, good and bad.
Negative_regulation (blocking) of PGs
1) Confidence 0.41 Published 2008 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 18802217 Disease Relevance 0.40 Pain Relevance 0.20
On the other hand, difficulties, with this method can arise from the small molecular weight of PGs and the large number of structurally closely related PGs and PG metabolites which cross-react in the various radioimmunoassays thus influencing the specificity of the method.
Negative_regulation (number) of PGs
2) Confidence 0.37 Published 1978 Journal Z Gastroenterol Section Abstract Doc Link 654390 Disease Relevance 0 Pain Relevance 0
Although PGs are shown to be effective in IOP reduction for chronic angle closure glaucoma, its effectiveness is unreliable if a quick reduction of IOP is desirable such as in acute angle closure attack, because of its relatively slow onset of action.


Negative_regulation (effective) of PGs associated with onset of action, glaucoma and ocular hypertension
3) Confidence 0.36 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701126 Disease Relevance 1.91 Pain Relevance 0.10
The objective of this study was to determine if indomethacin, at concentrations comparable to plasma and tissue levels obtained in humans taking therapeutic doses, predisposes human gastric cells to injury through inhibition of PGs or acts through an alternate mechanism.
Negative_regulation (inhibition) of PGs in plasma associated with injury
4) Confidence 0.34 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9756489 Disease Relevance 0.45 Pain Relevance 0.09
High levels of PGs in dysmenorrheic subjects, decrease of PGs concentration by naproxen treatment and simultaneous alleviation of pain suggest the involvement of PGs in the cause of dysmenorrhea.
Negative_regulation (decrease) of PGs associated with pain and dismenorea
5) Confidence 0.34 Published 1981 Journal Acta Obstet Gynaecol Jpn Section Abstract Doc Link 7234342 Disease Relevance 0.53 Pain Relevance 0.44
We tested the hypothesis that combined inhibition of nitric oxide (NO) and prostaglandins (PGs) restores sympathetic vasoconstriction in contracting human muscle.
Negative_regulation (inhibition) of PGs in sympathetic associated with increased venous pressure under development
6) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15271659 Disease Relevance 0.17 Pain Relevance 0.10
Thus in light of our previous findings, it appears that inhibition of either NO or PGs alone does not affect functional sympatholysis in healthy humans.
Negative_regulation (inhibition) of PGs
7) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15271659 Disease Relevance 0.25 Pain Relevance 0.41
After combined inhibition of NO and PGs, the vasoconstrictor responses to all alpha-adrenergic receptor stimuli were augmented by approximately 10% in contracting muscle (P <0.05), whereas the responses to phenylephrine and clonidine were also augmented by approximately 10% during passive vasodilation in resting muscle (P <0.05).
Negative_regulation (inhibition) of PGs in muscle associated with increased venous pressure under development and clonidine
8) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15271659 Disease Relevance 0.23 Pain Relevance 0.51
However, the results from the present study indicate that combined inhibition of NO and PGs augments alpha-adrenergic vasoconstriction in contracting muscle but does not completely restore the vasoconstrictor responses compared with those observed during passive vasodilation in resting muscle.
Negative_regulation (inhibition) of PGs in muscle associated with increased venous pressure under development
9) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15271659 Disease Relevance 0.35 Pain Relevance 0.38
Before combined inhibition of NO and PGs, the forearm vasoconstrictor responses to intra-arterial tyramine (which evoked endogenous noradrenaline release), phenylephrine (a selective alpha1-agonist), and clonidine (an alpha2-agonist) were significantly blunted during exercise compared with adenosine treatment.
Negative_regulation (inhibition) of PGs in forearm associated with adenocard, agonist, noradrenaline and clonidine
10) Confidence 0.30 Published 2004 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15271659 Disease Relevance 0.21 Pain Relevance 0.49
Calcitriol also repressed the mRNA expression of the PG receptors EP2 and FP, providing a potential additional mechanism of suppression of the biological activity of PGs.
Negative_regulation (suppression) of PGs
11) Confidence 0.27 Published 2005 Journal Cancer Res. Section Abstract Doc Link 16140963 Disease Relevance 0.56 Pain Relevance 0.17
Moreover, when the endogenous latent metalloproteases were activated with APMA, high-density PGs (the A1D1 fraction) showed a reduction in their capacity to reaggregate, and in their hydrodynamic size.
Negative_regulation (reduction) of PGs
12) Confidence 0.25 Published 1992 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 1505108 Disease Relevance 0.12 Pain Relevance 0.16
We postulate that this dual action of calcitriol would reduce the levels of biologically active PGs in PCa cells decreasing their proliferative stimulus and contribute to the growth inhibitory actions of calcitriol.
Negative_regulation (reduce) of PGs associated with reprotox - general 1
13) Confidence 0.24 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 16024246 Disease Relevance 0.71 Pain Relevance 0.12
It has been suggested that the degenerative process begins in the NP and is associated with the progressive loss of PGs [2].
Negative_regulation (loss) of PGs
14) Confidence 0.01 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2453768 Disease Relevance 0.52 Pain Relevance 0.25
There was a greater than 50% reduction in PG D2 production in clone 11 compared with the vector only control and a similar decrease in levels of PGs F2?
Negative_regulation (decrease) of PGs
15) Confidence 0.01 Published 2001 Journal BMC Biochem Section Body Doc Link PMC31925 Disease Relevance 0.15 Pain Relevance 0.04

General Comments

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