INT318305

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Context Info
Confidence 0.08
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.76
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NOD2, NLRP3) cytoplasm (NOD2, NLRP3) signal transduction (NLRP3)
plasma membrane (NOD2) enzyme binding (NOD2)
Anatomy Link Frequency
macrophages 1
monocytes 1
NOD2 (Homo sapiens)
NLRP3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 14 92.24 High High
tolerance 2 44.00 Quite Low
depression 2 30.72 Quite Low
Pain 2 26.08 Quite Low
methotrexate 8 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
headache 4 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 100 94.60 High High
Disease 16 90.68 High High
Metastasis 36 89.48 High High
Cancer 38 85.92 High High
Fever 8 58.64 Quite High
Chills 6 58.08 Quite High
Fatigue 10 31.44 Quite Low
Depression 2 30.72 Quite Low
Cognitive Disorder 2 29.76 Quite Low
Appetite Loss 4 28.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
L-MTP-PE most likely activates macrophages and monocytes via the same signaling pathways as does MDP (ie, recognition via NOD2 and NLRP3 and activation of NF-?
NOD2 Binding (recognition) of NLRP3 in monocytes
1) Confidence 0.08 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893760 Disease Relevance 0.88 Pain Relevance 0.08
L-MTP-PE most likely activates macrophages and monocytes via the same signaling pathways as does MDP (ie, recognition via NOD2 and NLRP3 and activation of NF-?
NOD2 Binding (recognition) of NLRP3 in macrophages
2) Confidence 0.03 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2893760 Disease Relevance 0.88 Pain Relevance 0.08

General Comments

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