INT318323

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Context Info
Confidence 0.34
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (GRB2, HSPA5) unfolded protein binding (HSPA5) cell differentiation (GRB2)
endosome (GRB2) anatomical structure formation involved in morphogenesis (GRB2) aging (GRB2)
GRB2 (Homo sapiens)
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 2 98.22 Very High Very High Very High
Serotonin 2 97.40 Very High Very High Very High
GABA receptor 2 96.98 Very High Very High Very High
Glutamate receptor 6 96.48 Very High Very High Very High
Neurotransmitter 4 95.90 Very High Very High Very High
addiction 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
long-term potentiation 1 5.00 Very Low Very Low Very Low
cocaine 1 5.00 Very Low Very Low Very Low
Nicotine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 100 84.56 Quite High
Disease 28 25.12 Quite Low
Cancer 44 5.00 Very Low Very Low Very Low
Mental Disorders 3 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Manic Depressive Disorder 1 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 1 5.00 Very Low Very Low Very Low
Alcohol Addiction 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Among the four well-known neurotransmitter pathways (glutamate receptor signaling, GABA receptor signaling, serotonin receptor signaling and dopamine receptor signaling), GRB2 appeared in all the four pathways and HSPA5 in three pathways, and the interaction between GRB2 and HSPA5 appeared in three pathways.
GRB2 Spec (appeared) Binding (interaction) of HSPA5 associated with neurotransmitter, dopamine receptor, gaba receptor, glutamate receptor and serotonin
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.28 Pain Relevance 0.31

General Comments

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