INT318429

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Context Info
Confidence 0.57
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Rad23b) nucleus (Rad23b) cytoplasm (Rad23b)
Rad23b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 93 86.20 High High
Inflammation 6 81.76 Quite High
chemokine 9 73.80 Quite High
analgesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 12 98.30 Very High Very High Very High
Cancer 12 97.34 Very High Very High Very High
Injury 84 92.56 High High
Cv Unclassified Under Development 93 86.20 High High
INFLAMMATION 6 81.76 Quite High
Lymphedema 3 63.12 Quite High
Reperfusion Injury 12 29.68 Quite Low
Myocardial Infarction 3 19.28 Low Low
Death 6 17.76 Low Low
Cv General 4 Under Development 3 9.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of Rad23b in hypoxic cancer cells could be partially reversed by antisense inhibition of miR-373 [37], indicating a key role of miR-373 in modulating the basal expression of Rad23b.
Gene_expression (expression) of Rad23b associated with cancer and hypoxia
1) Confidence 0.57 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.00 Pain Relevance 0.15
In monitoring the target genes of miR-21 in the expression array at 1, 3, 7, 14 d after reperfusion, with persistent expression throughout the experiment, we detected the same 4 persistently downregulated target genes (Nqo1, Pdpn, CXCL3, and Rad23b) with the prediction algorithms miRanda and RNAhybrid, but no target gene was revealed with PicTar, TargetScanS, and MirTarget2.


Gene_expression (detected) of Rad23b
2) Confidence 0.57 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.36 Pain Relevance 0.10
The effect of anti-miR-373 activity in normoxia is more profound than in hypoxia; thus, it has been suggested that there might be other mechanisms that regulate the expression of Rad23b [37].
Gene_expression (expression) of Rad23b associated with hypoxia
3) Confidence 0.57 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.96 Pain Relevance 0.14

General Comments

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