INT31843

Context Info Confidence 0.03 First Reported 1988 Last Reported 1988 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 2 Disease Relevance 0.34 Pain Relevance 0.34

extracellular region (Prl) plasma membrane (Grpr) signal transducer activity (Grpr)

Anatomy Link Frequency lactotrope 2 Grpr (Rattus norvegicus) Prl (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 4 100.00 Analgesic 2 25.00

Disease Link Frequency Relevance Heat Stress 4 100.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results show that bombesin given intravenously acts as an inhibitor of PRL secretion and suggests that it does not act on the lactotrope itself but rather by an increase of the inhibitory dopaminergic tone.

bombesin Negative_regulation (inhibitor) of Localization (secretion) of PRL in lactotrope

1) Confidence 0.03 Published 1988 Journal Life Sci. Section Abstract Doc Link 2904106 Disease Relevance 0.17 Pain Relevance 0.17

Intravenously administered bombesin lowered basal PRL levels in conscious male rats and prevented the morphine, bremazocine and stress-induced PRL secretion.

bombesin Negative_regulation (prevented) of Localization (secretion) of PRL associated with stress and morphine

2) Confidence 0.03 Published 1988 Journal Life Sci. Section Abstract Doc Link 2904106 Disease Relevance 0.17 Pain Relevance 0.17

General Comments

This test has worked.