INT318440

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.93
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 2
sciatic nerve 1
muscles 1
body 1
Mir21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Sciatic nerve 12 99.68 Very High Very High Very High
ischemia 256 98.92 Very High Very High Very High
beta blocker 1 75.08 Quite High
Inflammation 16 14.88 Low Low
chemokine 24 6.92 Low Low
analgesia 9 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 37 99.06 Very High Very High Very High
Cv Unclassified Under Development 256 98.92 Very High Very High Very High
Injury 244 98.12 Very High Very High Very High
Shock 8 98.00 Very High Very High Very High
Apoptosis 39 95.36 Very High Very High Very High
Death 19 94.80 High High
Nerve Compression Syndromes 30 91.52 High High
Cv General 4 Under Development 8 87.52 High High
Colon Cancer 1 87.28 High High
Reperfusion Injury 33 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Those upregulated miRNAs (miR-21, miR-200c, and miR-205) that were identified from the miRNA array were quantified by real-time RT-PCR with the Applied Biosystems 7500 (Applied Biosystems, USA).
Positive_regulation (upregulated) of miR-21
1) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0 Pain Relevance 0
In the experiment that we performed to identify the minimal ischemic time that would induce the expression of these 3 miRNAs, upregulation of miR-21 and miR-200c was noted after 4 h of reperfusion following 1 h and 2 h, but not 30 min of ischemia; in addition, upregulation of miR-205 was noted after 4 h of reperfusion following 2 h, but not 30 min or 1 h of ischemia (Figure 2).


Positive_regulation (upregulation) of miR-21 associated with ischemia
2) Confidence 0.33 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.77 Pain Relevance 0.23
As shown in Figure 1, the 2-fold upregulation of miR-21 was detected after 4 h of ischemia and increased to a maximum of ~24 fold at 7 d after reperfusion.
Positive_regulation (upregulation) of miR-21 associated with ischemia
3) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.39 Pain Relevance 0.16
In addition, a significant induction of miR-21 was noted in the heart following whole body heat-shock [19].
Positive_regulation (induction) of miR-21 in body associated with shock
4) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.11 Pain Relevance 0.03
In an investigation of rat hearts at 6 h after acute myocardial injury, miRNA signatures in the early phase revealed that, among multiple aberrantly expressed miRNAs, miR-21 was significantly downregulated in infarcted areas, but was upregulated in border areas [31].
Positive_regulation (upregulated) of miR-21 in hearts associated with injury
5) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.95 Pain Relevance 0
In this study, we demonstrated that 3 miRNAs (miR-21, miR-200c, and miR-205) were significantly upregulated in a different pattern in the gracilis muscles following ischemic injury.
Positive_regulation (upregulated) of miR-21 in muscles associated with injury
6) Confidence 0.22 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.52 Pain Relevance 0.13
Because bioinformatic analysis has indicated that miRNAs frequently interact with transcription factors in feedback and feedforward loops to regulate their target genes [43,44]; therefore, further experiments are required to elucidate the function and role of these potential target genes and the upregulated miR-21, as well as miR-200c and miR-205, in ischemic injury.
Positive_regulation (upregulated) of miR-21 associated with injury
7) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.71 Pain Relevance 0.08
Real-time RT-PCR demonstrated that, with 2-fold increase after 4 h of ischemia, a maximum 24-fold increase at 7 d, and a 7.5-fold increase at 14 d after reperfusion, only the miR-21, but not the miR-200c or miR-205 was upregulated throughout the experimental time.
Positive_regulation (upregulated) of miR-21 associated with ischemia
8) Confidence 0.19 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.42 Pain Relevance 0.14
We detected 1 downregulated miRNA (miR-144) and 1 upregulated miRNA (miR-21) after sciatic nerve denervation.
Positive_regulation (upregulated) of miR-21 in sciatic nerve associated with sciatic nerve
9) Confidence 0.09 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2927509 Disease Relevance 0.42 Pain Relevance 0.05
Treatment with resveratrol in cancer cell line SW480 results in decreased level of miR-21 and miR29c whereas it was increased in healthy heart when treated with resveratrol.
Positive_regulation (increased) of miR-21 in heart associated with cancer
10) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.64 Pain Relevance 0.04

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