INT318442

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Context Info
Confidence 0.24
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 4.60
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 3
Mir21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
beta blocker 1 75.84 Quite High
ischemia 132 56.04 Quite High
chemokine 12 5.00 Very Low Very Low Very Low
Inflammation 8 5.00 Very Low Very Low Very Low
analgesia 4 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 99.58 Very High Very High Very High
Cancer 21 99.44 Very High Very High Very High
Death 11 99.30 Very High Very High Very High
Injury 116 98.06 Very High Very High Very High
Shock 4 94.52 High High
Colon Cancer 1 88.04 High High
Myocardial Infarction 8 86.16 High High
Acute Monocytic Leukemia 1 86.08 High High
Coronary Artery Disease 4 74.08 Quite High
Cv Unclassified Under Development 132 56.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In an investigation of rat hearts at 6 h after acute myocardial injury, miRNA signatures in the early phase revealed that, among multiple aberrantly expressed miRNAs, miR-21 was significantly downregulated in infarcted areas, but was upregulated in border areas [31].
Negative_regulation (downregulated) of miR-21 in hearts associated with injury
1) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.94 Pain Relevance 0
Remarkably, the downregulation of miR-21 in infarcted areas was inhibited by ischemic preconditioning, a known cardio-protective method.
Negative_regulation (downregulation) of miR-21
2) Confidence 0.24 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.85 Pain Relevance 0
The hydrogen peroxide-induced cardiac cell death and apoptosis were increased by a miR-21 inhibitor and was decreased by pre-miR-21 transfection [30].
Negative_regulation (inhibitor) of miR-21 associated with apoptosis and death
3) Confidence 0.21 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.18 Pain Relevance 0.05
The injection of chemically synthesized exogenous miR-21 significantly reduced infarct size in the heart which was blocked with a miR-21 inhibitor [19].
Negative_regulation (inhibitor) of miR-21 in heart
4) Confidence 0.20 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.99 Pain Relevance 0
Treatment with resveratrol in cancer cell line SW480 results in decreased level of miR-21 and miR29c whereas it was increased in healthy heart when treated with resveratrol.
Negative_regulation (decreased) of miR-21 in heart associated with cancer
5) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0.64 Pain Relevance 0.04

General Comments

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