INT318449

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Context Info
Confidence 0.37
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 18
Total Number 20
Disease Relevance 11.92
Pain Relevance 1.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 2
gracilis 2
neurons 1
brain 1
heart 1
Mir21 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 357 99.48 Very High Very High Very High
Bioavailability 2 97.60 Very High Very High Very High
Sciatic nerve 48 70.68 Quite High
chemokine 33 55.92 Quite High
Inflammation 22 5.00 Very Low Very Low Very Low
analgesia 15 5.00 Very Low Very Low Very Low
anesthesia 9 5.00 Very Low Very Low Very Low
fibrosis 6 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Demyelination 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 357 99.48 Very High Very High Very High
Injury 380 99.24 Very High Very High Very High
Myocardial Infarction 19 98.88 Very High Very High Very High
Cancer 177 98.84 Very High Very High Very High
Hepatocellular Cancer 147 98.72 Very High Very High Very High
Shock 11 98.60 Very High Very High Very High
Brain Tumor 4 96.66 Very High Very High Very High
Metastasis 9 96.48 Very High Very High Very High
Colon Cancer 5 95.92 Very High Very High Very High
Liver Cancer 39 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The injection of chemically synthesized exogenous miR-21 significantly reduced infarct size in the heart which was blocked with a miR-21 inhibitor [19].
Gene_expression (synthesized) of miR-21 in heart
1) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.07 Pain Relevance 0
At 14 d, there was still a 7.5-fold increased expression of miR-21.
Gene_expression (expression) of miR-21
2) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.48 Pain Relevance 0.17
The overexpression of miR-21 has been shown to be in a number of medium-scale and high-scale profiling experiments that were designed for the detection of miRNAs that are dysregulated in cancer [27].
Gene_expression (overexpression) of miR-21 associated with cancer
3) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 1.17 Pain Relevance 0.11
However, as shown in the Figure 2, in the investigation of minimal ischemic time that would induce the expression of these 3 miRNAs, we had demonstrated that 1 h of ischemia was able to increase the expression of miR-21 and miR-200c and 2 h of ischemia would increase the expression of these three miRNAs, implying the epigenetic regulation could be induced by a shorter time of ischemia before a remarked pathophysiologic change could be observed by a longer time of ischemia.
Gene_expression (expression) of miR-21 associated with ischemia
4) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.88 Pain Relevance 0.35
This study has profiled an increased expression of miR-21, miR-200c, and miR-205 in the gracilis muscle following ischemic injury and identified four potential target genes (Nqo1, Pdpn, CXCL3, and Rad23b) of the miR-21 by using different prediction algorithms and monitoring the expression of miRNA and mRNA at different time point on a genome-wide basis.
Gene_expression (expression) of miR-21 in gracilis associated with injury
5) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.23 Pain Relevance 0.03
In addition, adenoviral overexpression of miR-21 had a protective effect on myocardial infarction by decreasing the infarct size by 29% at 24 h [31].
Gene_expression (overexpression) of miR-21 associated with myocardial infarction
6) Confidence 0.37 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.77 Pain Relevance 0
Ischemia for only 1 h was sufficient to induce the expression of miR-21 and miR-200c during the reperfusion stage; and 2 h of ischemia were required to induce the expression of miR-205.
Gene_expression (expression) of miR-21 associated with ischemia
7) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.57 Pain Relevance 0.14
Three miRNAs (miR-21, miR-200c, and miR-205) of 350 tested rat miRNAs were found to have an increased expression in the miRNA array.
Gene_expression (expression) of miR-21
8) Confidence 0.29 Published 2010 Journal BMC Musculoskelet Disord Section Abstract Doc Link PMC2894749 Disease Relevance 0.45 Pain Relevance 0.16
In contrast, the expression of miR-21 gradually increased to its maximum level at 7 d and persisted throughout the experiment for at least 14 d after the ischemic injury.
Gene_expression (expression) of miR-21 associated with injury
9) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.94 Pain Relevance 0.13
Therefore, we decided to only focus on the genes that were downregulated by miR-21, which showed a persistent expression throughout the experiment period at all 4 indicated times.
Gene_expression (expression) of miR-21
10) Confidence 0.25 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.34 Pain Relevance 0.06
It is highly expressed in glioblastomas and functions as an oncogenic and anti-apoptotic factor, while it is expressed at basal levels in other brain tumors and in the normal brain [37,38]. miR-21 was reported to play a cytoprotective role against injury via its target genes [39,40]; however, the role and target genes of miR-21 expression in the DRGs after denervation were beyond the scope of this study.
Gene_expression (expression) of miR-21 in brain associated with glioblastoma, injury, apoptosis and brain tumor
11) Confidence 0.18 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.53 Pain Relevance 0
Additionally, it has been verified that miR-21 overexpression can down-regulate the Pdcd4 tumor suppressor and stimulate invasion, intravasation and metastasis in colorectal cancer [31].
Gene_expression (overexpression) of miR-21 associated with cancer, colon cancer and metastasis
12) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 1.30 Pain Relevance 0
Here we validated significant overexpression of miR-10b, miR-21, and miR-34c-3p in SP fractions of HCC compared to SP fractions of normal fetal liver cells.
Gene_expression (overexpression) of miR-21 in liver associated with hepatocellular cancer
13) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 1.38 Pain Relevance 0
As shown in Figure 4A, the results showed that the expression levels of miR-21, miR-34c-3p, miR-16, miR-10b, and let-7i* in SP of HCC cells compared to SP of fetal liver cells were increased 3.5 ± 0.84, 2.1 ± 0.52, 2.2 ± 0.46, 3.9 ± 0.61, and 2.8 ± 0.25 -fold respectively, which were consistent with miRNA microarray results (P < 0.05). of the down-regulated miR-200a*, and miR-148b* in SP of HCC cells had the fold changes 0.1 ± 0.04, and 0.4 ± 0.08, respectively (P < 0.01).
Gene_expression (expression) of miR-21 in liver associated with hepatocellular cancer
14) Confidence 0.16 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC3022676 Disease Relevance 0.49 Pain Relevance 0
In this study, we had demonstrated an ~6-fold increase in the expression of miR-21 in DRG neurons at 1 week after denervation that lasted for up to 6 months. miR-21 is one of the most prominent miRNAs implicated in human malignancies [36].
Gene_expression (expression) of miR-21 in neurons
15) Confidence 0.16 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0.68 Pain Relevance 0
We used in situ hybridization to localize miR-21 expression in the DRG sections.
Gene_expression (expression) of miR-21
16) Confidence 0.16 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0 Pain Relevance 0
There was a tremendous upregulation of miR-21 expression in basal level controls with resveratrol (up 391.4) and longevinex (760.9) which was lowered considerably in IR (up 61.5 and 59.3). miR-539 is upregulated to high level (214 fold) in IR samples and were further up-regulated in resveratrol preteated samples.
Gene_expression (expression) of miR-21
17) Confidence 0.13 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009730 Disease Relevance 0 Pain Relevance 0.05
In the investigation of the differentially expressed miRNAs from the miRNA array experiments, there were only 3 miRNAs (miR-21, miR-200c, and miR-205) that showed an increased expression in the gracilis muscles after 4 h of ischemia and 4 h of reperfusion.
Gene_expression (expression) of miR-21 in gracilis associated with ischemia
18) Confidence 0.13 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2894749 Disease Relevance 0.22 Pain Relevance 0.11
Real time RT-PCR revealed that the expression of miR-21 in the DRGs was detected after 1 week of denervation with an ~6-fold increase that lasted for up to 6 months (Figure 2D).
Gene_expression (expression) of miR-21
19) Confidence 0.12 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2927509 Disease Relevance 0 Pain Relevance 0.04
Differential expression was observed in over 25 miRNAs, some of them, such as miR-21 were previously implicated in cardiac remodeling.
Gene_expression (expression) of miR-21
20) Confidence 0.10 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC3009730 Disease Relevance 0.43 Pain Relevance 0.11

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