INT318459

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Context Info
Confidence 0.60
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 14
Disease Relevance 9.92
Pain Relevance 8.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Nnat)
Anatomy Link Frequency
neurons 6
peripheral nerve 6
neuronal 2
fat 2
endothelial cells 2
Nnat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 294 99.84 Very High Very High Very High
c fibre 140 99.84 Very High Very High Very High
Peripheral nerve injury 84 99.84 Very High Very High Very High
Sciatic nerve 238 99.82 Very High Very High Very High
Hyperalgesia 84 99.26 Very High Very High Very High
unmyelinated 84 98.68 Very High Very High Very High
chemokine 28 97.76 Very High Very High Very High
cytokine 28 97.28 Very High Very High Very High
Pain 42 96.92 Very High Very High Very High
Inflammation 42 96.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nervous System Injury 112 99.88 Very High Very High Very High
Ganglion Cysts 420 99.84 Very High Very High Very High
Hyperalgesia 84 99.26 Very High Very High Very High
Adhesions 28 98.52 Very High Very High Very High
Pain 126 96.92 Very High Very High Very High
INFLAMMATION 70 96.88 Very High Very High Very High
Neuropathic Pain 266 93.72 High High
Stress 42 91.40 High High
Necrosis 28 70.96 Quite High
Cancer 28 70.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This suggested that the increased expression of total Nnat was induced by peripheral nerve injury.
Positive_regulation (increased) of Gene_expression (expression) of Nnat in peripheral nerve associated with nervous system injury and peripheral nerve injury
1) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.85 Pain Relevance 0.67
This suggested that the increased expression of total Nnat was induced by peripheral nerve injury.
Positive_regulation (induced) of Gene_expression (expression) of Nnat in peripheral nerve associated with nervous system injury and peripheral nerve injury
2) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.80 Pain Relevance 0.67
To investigate whether the increased expression of Nnat found by our previous work with Affymetrix arrays was consistent with increased protein expression, left L4-L5 DRGs from 3 rats of control and experimental group (post-axotomy day 1, 3, 5, and 7) were pooled for Western blotting in triplicate (n = 9 for each group) to analyze total Nnat (Nnat-?
Positive_regulation (increased) of Gene_expression (expression) of Nnat associated with ganglion cysts
3) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.28 Pain Relevance 0.22
Although it is not clear why Nnat expression was increased in DRG cells of axotomized rat, it is possible that a peripheral nerve injury such as axotomy of sciatic nerve, being one of the most used animal models of neuropathic pain, is able to create a "micro-environment" stress strong enough to trigger undergoing epigenetic modifications in Nnat leading to unexpected increased expression in adult DRG cells.
Positive_regulation (increased) of Gene_expression (expression) of Nnat in peripheral nerve associated with stress, dorsal root ganglion, nervous system injury, neuropathic pain, sciatic nerve and peripheral nerve injury
4) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.29 Pain Relevance 0.81
Their results showed that overexpression of Nnat in HAECs or in mouse carotid artery would induce increased expression of a panel of nuclear factor-kappaB (NF-?
Positive_regulation (overexpression) of Gene_expression (overexpression) of Nnat in carotid artery
5) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.23 Pain Relevance 0.13
To investigate the function of Nnat, they used recombinant adenovirus (Ad-Nnat) to overexpress the Nnat gene in primary human aortic endothelial cells (HAECs) and in the mouse aorta in vivo.
Positive_regulation (overexpress) of Gene_expression (overexpress) of Nnat in endothelial cells
6) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.22 Pain Relevance 0.12
Furthermore, according to the immunohistochemical results, it showed that after the sciatic nerve was axotomized, the subcellular localization of Nnat in DRG was confirmed by peripherin-positive neuronal cells, where the expression of Nnat was also increased.
Positive_regulation (increased) of Gene_expression (expression) of Nnat in neuronal associated with dorsal root ganglion and sciatic nerve
7) Confidence 0.60 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.77 Pain Relevance 0.78
Therefore, the scenario we speculate here is that sciatic nerve transection in adult rats might create a stressful micro-environment strong enough to trigger epigenetic modifications on the expression of Nnat, notably increasing it to a significant degree in a selective subpopulation of adult DRG neurons, specifically in sensory C and A-?
Positive_regulation (increasing) of Gene_expression (expression) of Nnat in neurons associated with dorsal root ganglion and sciatic nerve
8) Confidence 0.43 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.85 Pain Relevance 0.91
They suggested that this effect of Nnat in both db/db and high-fat diet-fed mouse aortas was mediated through phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase-dependent activation of NF-?
Positive_regulation (through) of Gene_expression (effect) of Nnat in fat
9) Confidence 0.43 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 0.33 Pain Relevance 0.15
It was found that after nerve injury, the expression of Nnat was increased in total protein extracts.
Positive_regulation (increased) of Gene_expression (expression) of Nnat in nerve associated with nervous system injury
10) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2894761 Disease Relevance 0.69 Pain Relevance 0.63
The increased expression of Nnat and its subcellular localization were related to mechanical hyperalgesia.


Positive_regulation (increased) of Gene_expression (expression) of Nnat associated with hyperalgesia
11) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2894761 Disease Relevance 0.71 Pain Relevance 0.64
Our data showed that axotomy of sciatic nerve in adult rats induced an increased expression of Nnat in DRG neurons, specifically in unmyelinated C-fiber and thinly myelinated A-?
Positive_regulation (induced) of Gene_expression (expression) of Nnat in neurons associated with c fibre, dorsal root ganglion, sciatic nerve and unmyelinated
12) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.12 Pain Relevance 1.01
Our data showed that axotomy of sciatic nerve in adult rats induced an increased expression of Nnat in DRG neurons, specifically in unmyelinated C-fiber and thinly myelinated A-?
Positive_regulation (increased) of Gene_expression (expression) of Nnat in neurons associated with c fibre, dorsal root ganglion, sciatic nerve and unmyelinated
13) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2894761 Disease Relevance 1.12 Pain Relevance 1.01
The results indicated that there was significant correlation between mechanical hyperalgesia in axotomy of sciatic nerve and the increased expression of Nnat in C-fiber and A-?
Positive_regulation (increased) of Gene_expression (expression) of Nnat in sciatic nerve associated with c fibre, hyperalgesia and sciatic nerve
14) Confidence 0.40 Published 2010 Journal J Biomed Sci Section Abstract Doc Link PMC2894761 Disease Relevance 0.67 Pain Relevance 0.75

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