INT318473

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0.46
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (CA2) Golgi apparatus (OPRM1) endoplasmic reticulum (OPRM1)
response to stress (CA2) cytoplasm (CA2) signal transducer activity (OPRM1)
OPRM1 (Homo sapiens)
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 54 100.00 Very High Very High Very High
narcan 22 98.84 Very High Very High Very High
Opioid 54 90.12 High High
Hyperalgesia 32 79.08 Quite High
tolerance 28 78.76 Quite High
opioid receptor 68 75.00 Quite High
analgesia 8 71.72 Quite High
addiction 4 68.88 Quite High
Analgesic 24 68.00 Quite High
Pain 6 56.68 Quite High
Disease Link Frequency Relevance Heat
Neuroblastoma 10 97.12 Very High Very High Very High
Hyperalgesia 38 79.08 Quite High
Pain 8 56.68 Quite High
Ganglion Cysts 14 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Bordatella Infection 6 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 2 5.00 Very Low Very Low Very Low
Depression 2 5.00 Very Low Very Low Very Low
Post Operative Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In BE2C cells, stimulation of MOR1K with morphine produced a robust dose-dependent increase in Ca2+ levels that was blocked by naloxone.
Positive_regulation (stimulation) of MOR1K Positive_regulation (increase) of Ca2 associated with narcan and morphine
1) Confidence 0.17 Published 2010 Journal Mol Pain Section Body Doc Link PMC2894766 Disease Relevance 0.18 Pain Relevance 0.85
In contrast to stimulation of MOR1, stimulation of MOR1K leads to increased Ca2+ levels as well as increased nitric oxide (NO) release.
Positive_regulation (stimulation) of MOR1K Positive_regulation (increased) of Ca2
2) Confidence 0.17 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2894766 Disease Relevance 0.28 Pain Relevance 1.28

General Comments

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