INT318478

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.38
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) plasma membrane (LTB4R) nucleus (IRF6)
DNA binding (IRF6) signal transducer activity (LTB4R) cytoplasm (IRF6)
IRF6 (Homo sapiens)
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 42 99.98 Very High Very High Very High
Inflammation 56 94.64 High High
corticosteroid 62 79.20 Quite High
Inflammatory response 2 78.56 Quite High
cytokine 6 42.08 Quite Low
agonist 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Versed 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 202 98.92 Very High Very High Very High
INFLAMMATION 56 94.64 High High
Occupational Lung Diseases 74 93.00 High High
Nicotine Addiction 8 5.00 Very Low Very Low Very Low
Adhesions 6 5.00 Very Low Very Low Very Low
Rhinitis 6 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Sleep Disorders 2 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexamethasone inhibited LPS-induced LTB4 and LXA4, with lesser suppression of LTB4 in severe asthma patients (p < 0.05).
Negative_regulation (inhibited) of LPS Positive_regulation (induced) of LTB4 associated with asthma and dexamethasone
1) Confidence 0.01 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.00 Pain Relevance 0.23
In addition, while the LPS-induced LTB4 was largely suppressed by dexamethasone, it was only partly suppressed in AMs from severe asthma patients; by contrast, induced generation of LXA4 was suppressed in all three groups.
Negative_regulation (suppressed) of LPS Positive_regulation (induced) of LTB4 associated with asthma and dexamethasone
2) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.38 Pain Relevance 0.29

General Comments

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