INT318481

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Context Info
Confidence 0.14
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.09
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) cell adhesion (FPR2) plasma membrane (FPR2)
nucleus (IRF6) DNA binding (IRF6) signal transducer activity (FPR2)
Anatomy Link Frequency
alveolar macrophages 2
IRF6 (Homo sapiens)
FPR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 112 92.56 High High
dexamethasone 84 80.88 Quite High
corticosteroid 124 72.56 Quite High
Inflammatory response 4 48.72 Quite Low
cytokine 12 12.24 Low Low
agonist 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 404 100.00 Very High Very High Very High
Occupational Lung Diseases 148 99.76 Very High Very High Very High
INFLAMMATION 112 92.56 High High
Apoptosis 4 26.56 Quite Low
Nicotine Addiction 16 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Rhinitis 12 5.00 Very Low Very Low Very Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The LXA4 production induced by LPS is shown as the increment in LXA4 above baseline (Figure 1B).
LPS Positive_regulation (induced) of Gene_expression (production) of LXA4
1) Confidence 0.14 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 0.96 Pain Relevance 0.06
The LPS induced formation of LTB4 was higher in severe asthma compared to non-severe asthma and normal subjects, while the LPS induced production of LXA4 was significantly impaired in severe asthmatics compared to normal subjects, but to a similar extent as in non-severe asthma patients.
LPS Positive_regulation (induced) of Gene_expression (production) of LXA4 associated with asthma and occupational lung diseases
2) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.45 Pain Relevance 0.26
The LPS induced formation of LTB4 was higher in severe asthma compared to non-severe asthma and normal subjects, while the LPS induced production of LXA4 was significantly impaired in severe asthmatics compared to normal subjects, but to a similar extent as in non-severe asthma patients.
LPS Positive_regulation (induced) of Gene_expression (production) of LXA4 associated with asthma and occupational lung diseases
3) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.51 Pain Relevance 0.27
These results are in line with the current observation of reduced basal and LPS-stimulated production of LXA4 from alveolar macrophages of patients with severe asthma.
LPS Positive_regulation (stimulated) of Gene_expression (production) of LXA4 in alveolar macrophages associated with asthma
4) Confidence 0.10 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.17 Pain Relevance 0

General Comments

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