INT318490

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 4.39
Pain Relevance 1.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IRF6) plasma membrane (LTB4R) nucleus (IRF6)
DNA binding (IRF6) signal transducer activity (LTB4R) cytoplasm (IRF6)
IRF6 (Homo sapiens)
LTB4R (Homo sapiens)
Pain Link Frequency Relevance Heat
dexamethasone 84 99.78 Very High Very High Very High
corticosteroid 124 99.68 Very High Very High Very High
Inflammation 112 97.52 Very High Very High Very High
Inflammatory response 4 76.72 Quite High
cytokine 12 40.24 Quite Low
agonist 4 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 404 99.92 Very High Very High Very High
INFLAMMATION 112 97.52 Very High Very High Very High
Occupational Lung Diseases 148 97.16 Very High Very High Very High
Nicotine Addiction 16 5.00 Very Low Very Low Very Low
Adhesions 12 5.00 Very Low Very Low Very Low
Rhinitis 12 5.00 Very Low Very Low Very Low
Pulmonary Disease 8 5.00 Very Low Very Low Very Low
Sleep Disorders 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, while the LPS-induced LTB4 was largely suppressed by dexamethasone, it was only partly suppressed in AMs from severe asthma patients; by contrast, induced generation of LXA4 was suppressed in all three groups.
LPS Positive_regulation (induced) of LTB4 associated with asthma and dexamethasone
1) Confidence 0.01 Published 2010 Journal Respir Res Section Body Doc Link PMC2894769 Disease Relevance 1.38 Pain Relevance 0.29
Dexamethasone inhibited LPS-induced LTB4 and LXA4, with lesser suppression of LTB4 in severe asthma patients (p < 0.05).
LPS Positive_regulation (induced) of LTB4 associated with asthma and dexamethasone
2) Confidence 0.01 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 0.99 Pain Relevance 0.23
Decreased LXA4 and increased LTB4 generation plus impaired corticosteroid sensitivity of LPS-induced LTB4 but not of LXA4 support a role for AMs in establishing a pro-inflammatory balance in severe asthma.



LPS Neg (not) Positive_regulation (induced) of LTB4 associated with asthma, corticosteroid and inflammation
3) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.00 Pain Relevance 0.27
LPS-induced LTB4 was increased in severe asthma compared to non-severe asthma (p < 0.05).
LPS Positive_regulation (induced) of LTB4 associated with asthma
4) Confidence 0.00 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2894769 Disease Relevance 1.02 Pain Relevance 0.23

General Comments

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