INT318545

Context Info Confidence 0.20 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.39 Pain Relevance 0

peptidase activity (Adamts1) extracellular region (Adamts1) proteinaceous extracellular matrix (Adamts1)

Anatomy Link Frequency blood vessel 1 Adamts1 (Mus musculus) Tsp1 (Mus musculus)

Pain Link Frequency Relevance Heat metalloproteinase 6 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Cancer 220 98.08 Prostate Cancer 50 72.48 Metastasis 12 40.80 Malignant Neoplastic Disease 6 40.48 Vascular Tissue Neoplasms 2 37.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Instead, the total protein levels of detected TSP1 were markedly affected by ADAMTS1 levels.

ADAMTS1 Regulation (affected) of TSP1

1) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.70 Pain Relevance 0

Thus, the ADAMTS1-mediated effect on TSP1 levels could be a possible mechanism responsible for the switch in blood vessel morphology observed.

ADAMTS1 Regulation (effect) of TSP1 in blood vessel

2) Confidence 0.20 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2894797 Disease Relevance 0.69 Pain Relevance 0

General Comments

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