INT318612

Context Info Confidence 0.29 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.60 Pain Relevance 0.06

cytosol (Ngfrap1) nucleus (Ngfrap1) cytoplasm (Ngfrap1)

Ngfrap1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Inflammatory response 18 67.44 Spinal cord 21 59.68 Inflammation 8 44.00 cytokine 1 22.48 bDMF 6 5.00 Trk A 4 5.00 trk B 3 5.00 ketamine 2 5.00 trk C 2 5.00 Central nervous system 1 5.00

Disease Link Frequency Relevance Heat Injury 42 97.64 Apoptosis 47 81.00 Spinal Cord Injury 42 78.08 Intraoperative Complications 1 72.08 INFLAMMATION 26 67.44 Death 19 63.68 Spinal Injuries 6 17.28 Contusions 13 5.00 Nervous System Malformation 6 5.00 Stress 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The findings from the present study, demonstrating a significant down-regulation in the gene for Unc5a, a receptor which mediates the chemorepulsive effect of netrin-1 during development [52], could be related to the success of regrowth, as could the down-regulation of both Lingo1 [27,53] and Ngfrap1[54], receptors that mediate inhibitory cues from the post-injury environment.

Regulation (regulation) of Ngfrap1 associated with injury

1) Confidence 0.29 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2894843 Disease Relevance 0.60 Pain Relevance 0.06

General Comments

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