INT318673

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Context Info
Confidence 0.41
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.51
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Xbp1) DNA binding (Xbp1)
Xbp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 59 95.72 Very High Very High Very High
Kinase C 1 65.28 Quite High
carbamazepine 9 53.68 Quite High
Inflammation 4 38.96 Quite Low
Lamotrigine 23 17.44 Low Low
bDMF 16 5.00 Very Low Very Low Very Low
depression 11 5.00 Very Low Very Low Very Low
anticonvulsant 8 5.00 Very Low Very Low Very Low
gABA 7 5.00 Very Low Very Low Very Low
Gabapentin 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 53 95.72 Very High Very High Very High
Stress 63 93.04 High High
Apoptosis 62 91.84 High High
Manic Depressive Disorder 125 89.60 High High
Disease 9 82.88 Quite High
Injury 8 58.16 Quite High
Lung Injury 14 52.16 Quite High
INFLAMMATION 4 38.96 Quite Low
Adult Respiratory Distress Syndrome 2 32.20 Quite Low
Adverse Drug Reaction 6 17.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results demonstrate that taurine downregulates the levels of ATF4, XBP-1, and CHOP mRNA.
Negative_regulation (downregulates) of XBP-1
1) Confidence 0.41 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.61 Pain Relevance 0.04
When compared with the effects of taurine, the RT-PCR results indicated that ATF4, XBP-1, and CHOP mRNA levels decreased respectively.
Negative_regulation (decreased) of XBP-1
2) Confidence 0.41 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.58 Pain Relevance 0.05
The study showed an association between the G allele (that is associated with reduced transcription activity of XBP1) and a better response to VPA as compared to the C allele.
Negative_regulation (reduced) of XBP1
3) Confidence 0.21 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.32 Pain Relevance 0.06

General Comments

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