INT318674

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Context Info
Confidence 0.69
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.26
Pain Relevance 0.10

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Atf4) cytoskeleton (Atf4) nucleus (Atf4)
DNA binding (Atf4) microtubule organizing center (Atf4) cytoplasm (Atf4)
Anatomy Link Frequency
limbs 2
Atf4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 60 95.80 Very High Very High Very High
Spinal cord 62 50.00 Quite Low
Inflammation 6 48.68 Quite Low
Neurotransmitter 10 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
GABAergic 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
nMDA receptor 4 5.00 Very Low Very Low Very Low
Dopamine 4 5.00 Very Low Very Low Very Low
dopamine receptor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 54 95.80 Very High Very High Very High
Stress 62 93.60 High High
Apoptosis 58 92.12 High High
Injury 140 68.72 Quite High
INFLAMMATION 10 48.68 Quite Low
Adult Respiratory Distress Syndrome 2 41.92 Quite Low
Lung Injury 14 14.96 Low Low
Spinal Cord Injury 38 5.00 Very Low Very Low Very Low
Spasticity 36 5.00 Very Low Very Low Very Low
Repression 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ATF4 mRNA and XBP1 mRNA, which were present in control rats and had increased markedly in the lungs which limbs underwent 4h of ischemia and 4h of reperfusion.
Transcription (mRNA) of ATF4 in limbs associated with ischemia
1) Confidence 0.69 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.51 Pain Relevance 0.05
The gene of transcription factor ATF4 (Atf4) belongs to cluster profile 10 showing a late up-regulation.
Transcription (transcription) of Atf4
2) Confidence 0.66 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.12 Pain Relevance 0
The gene of transcription factor ATF4 (Atf4) belongs to cluster profile 10 showing a late up-regulation.
Transcription (transcription) of factor ATF4
3) Confidence 0.57 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2900267 Disease Relevance 0.12 Pain Relevance 0
ATF4 mRNA and XBP1 mRNA, which were present in control rats and had increased markedly in the lungs which limbs underwent 4h of ischemia and 4h of reperfusion.
Transcription (mRNA) of ATF4 in limbs associated with ischemia
4) Confidence 0.51 Published 2010 Journal Acta Orthopaedica Section Body Doc Link PMC2895349 Disease Relevance 0.51 Pain Relevance 0.05

General Comments

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