INT31874

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Context Info
Confidence 0.42
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 31
Total Number 31
Disease Relevance 12.22
Pain Relevance 20.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat)
Anatomy Link Frequency
striatum 10
cortex 5
medial 3
frontal cortex 3
plasma 2
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 528 100.00 Very High Very High Very High
Glutamate 315 100.00 Very High Very High Very High
Dopamine 294 100.00 Very High Very High Very High
Serotonin 77 100.00 Very High Very High Very High
Spinal cord 14 100.00 Very High Very High Very High
Thermal hyperalgesia 2 100.00 Very High Very High Very High
Endep 4 99.98 Very High Very High Very High
Hippocampus 42 99.88 Very High Very High Very High
Cannabinoid 5 99.78 Very High Very High Very High
Eae 20 99.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Chronic Renal Failure 37 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Injury 108 99.76 Very High Very High Very High
Manic Depressive Disorder 79 99.50 Very High Very High Very High
Depression 37 99.48 Very High Very High Very High
Necrosis 30 99.48 Very High Very High Very High
Cv Unclassified Under Development 366 99.44 Very High Very High Very High
Pain 5 99.44 Very High Very High Very High
Nervous System Injury 12 99.40 Very High Very High Very High
Generalized Anxiety Disorder 95 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that NO may be directly acting on GABA nerve terminals and tonically inhibiting GABA release or synthesis under basal conditions.
Negative_regulation (inhibiting) of Gene_expression (synthesis) of GABA in nerve associated with gaba
1) Confidence 0.42 Published 1995 Journal Neuroreport Section Abstract Doc Link 7488740 Disease Relevance 0 Pain Relevance 0.45
Amitriptyline prevents thermal hyperalgesia and modifications in rat spinal cord GABA(B) receptor expression and function in an animal model of neuropathic pain.
Negative_regulation (prevents) of Gene_expression (expression) of GABA in spinal cord associated with gaba, thermal hyperalgesia, neuropathic pain, endep and spinal cord
2) Confidence 0.41 Published 2005 Journal Biochem. Pharmacol. Section Title Doc Link 16293232 Disease Relevance 0.74 Pain Relevance 1.48
Acute stress induced with formalin (pain) resulted in a significant depletion of levels of GABA in the hypothalamus and the lower brainstem but not in the cortical areas.
Negative_regulation (depletion) of Gene_expression (levels) of GABA in hypothalamus associated with stress, medulla, pain and gaba
3) Confidence 0.38 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 3092127 Disease Relevance 0.27 Pain Relevance 0.56
When the rat striatum was perfused with artificial CSF containing 200 nM MnCl(2), the levels of GABA in the perfusate were remarkably decreased, while the levels of glutamate, aspartate, and glycine in the perfusate were not appreciably decreased.
Negative_regulation (decreased) of Gene_expression (levels) of GABA in striatum associated with glutamate and gaba
4) Confidence 0.38 Published 2003 Journal Brain Res. Section Abstract Doc Link 12591147 Disease Relevance 0 Pain Relevance 0.39
Picrotoxin and pentylenetetrazol, GABA antagonists, and 3-mercaptopropionic acid, an inhibitor of GABA biosynthesis, strongly inhibited the pentobarbital-stimulated gastric acid secretion.
Negative_regulation (inhibitor) of Gene_expression (biosynthesis) of GABA associated with gaba and antagonist
5) Confidence 0.38 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 3396625 Disease Relevance 0.08 Pain Relevance 0.44
The drug intake in a single doze of 10 mg/kg is accompanied by a decrease in the levels of dopamine, serotonin, and GABA in the cerebellum.
Negative_regulation (decrease) of Gene_expression (levels) of GABA in cerebellum associated with gaba, dopamine and serotonin
6) Confidence 0.38 Published 2009 Journal Eksp Klin Farmakol Section Abstract Doc Link 19928568 Disease Relevance 0.10 Pain Relevance 0.63
Muscimol prevents long-lasting potentiation of dorsal horn field potentials in rats with chronic constriction injury exhibiting decreased levels of the GABA transporter GAT-1.
Negative_regulation (decreased) of Gene_expression (levels) of GABA in dorsal horn associated with gaba, eae, injury and dorsal horn
7) Confidence 0.37 Published 2003 Journal Pain Section Title Doc Link 14499453 Disease Relevance 0.81 Pain Relevance 0.81
The activity of pyruvate and 2-oxoglutarate dehydrogenase complexes reduced significantly in the tissue of the damaged hemisphere, ALT activity increased sharply, AST activity grew slowly, the production of GABA in the glutamate decarboxylase reaction was slightly inhibited and its utilization in the GABA transaminase reaction was clearly accelerated.
Negative_regulation (inhibited) of Gene_expression (production) of GABA associated with glutamate and gaba
8) Confidence 0.36 Published 1988 Journal Zh Vopr Neirokhir Im N N Burdenko Section Abstract Doc Link 2905562 Disease Relevance 0.16 Pain Relevance 0.49
One, probably originating from the striatum, may be depressed via presynaptic 5-HT1B and GABA(B) receptors.
Negative_regulation (depressed) of Gene_expression (presynaptic) of GABA in striatum associated with gaba
9) Confidence 0.32 Published 1996 Journal J. Neurosci. Section Abstract Doc Link 8922413 Disease Relevance 0.07 Pain Relevance 0.90
However, only GABA was decreased relative to the neuronal marker NSE (neuron-specific enolase), indicating a disproportionate loss of GABA production following chronic silencing.
Negative_regulation (loss) of Gene_expression (production) of GABA in neuronal associated with gaba
10) Confidence 0.28 Published 1994 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 7900543 Disease Relevance 0.13 Pain Relevance 0.90
Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) protein.
Negative_regulation (Decrease) of Gene_expression (synthesis) of GABA in cortex associated with gaba and generalized anxiety disorder
11) Confidence 0.25 Published 2001 Journal Brain Res. Section Title Doc Link 11578600 Disease Relevance 1.07 Pain Relevance 0.34
An analysis of unitary IPSCs suggests that presynaptic GABA release is reduced after CCI and SNI.
Negative_regulation (reduced) of Gene_expression (presynaptic) of GABA associated with gaba, nervous system injury and eae
12) Confidence 0.23 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12151551 Disease Relevance 1.49 Pain Relevance 0.80
Decrease of nigral GAD-expression should result in the reduction of GABA synthesis and release in SN, which may decrease the inhibition on DAergic neurons to play a role in Parkinsonism development after forebrain ischemia.

6.3.

Negative_regulation (reduction) of Gene_expression (synthesis) of GABA in forebrain associated with parkinson's disease, gaba, generalized anxiety disorder, ischemia and substantia nigra
13) Confidence 0.22 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.69 Pain Relevance 0.55
Attempts to categorize AED according to their molecular targets have generally assigned them to three main groups; those that block voltage gated ion channels (Na and Ca), and those that either enhance GABAergic inhibition (by altering GABA synthesis/breakdown or potentiating GABAA-receptor (GABAAr) activity) or reduce glutamatergic excitation (blocking glutamate receptors, reducing glutamate release) (e.g.
Negative_regulation (breakdown) of Gene_expression (synthesis) of GABA associated with glutamate, gaba, glutamate receptor, gabaergic and antiepileptic drug
14) Confidence 0.17 Published 2010 Journal Neuroscience Section Body Doc Link PMC2877872 Disease Relevance 0.07 Pain Relevance 0.43
But, multi-ischemic insults instead of a single ischemic event induced a significantly higher extracellular glutamate level and reduced synthesis of GABA, resulting in a significantly higher excitotoxic index (i.e., (glutamate × glycine)/GABA) in the injured regions at 3 hours after reperfusion [15].
Negative_regulation (reduced) of Gene_expression (synthesis) of GABA associated with gaba and glutamate
15) Confidence 0.16 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.72 Pain Relevance 0.90
The result suggests that decreased synthesis of GABA might contribute to the enhanced ischemic injury in the striatum.
Negative_regulation (decreased) of Gene_expression (synthesis) of GABA in striatum associated with gaba and injury
16) Confidence 0.16 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.78 Pain Relevance 0.87
GABAergic efferent neurons in striatum are highly vulnerable to ischemia; GAD67-immunoreactivity markedly decreases associated with the death of striatal efferent neurons in the lesioned dorsal striatum and markedly decreases the GABA synthesis in SRN induced by global ischemia [17].
Negative_regulation (decreases) of Gene_expression (synthesis) of GABA in striatum associated with gaba, ischemia, gabaergic and death
17) Confidence 0.16 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.90 Pain Relevance 0.47
The dorsolateral striatum has profound neuronal necrosis associated with a marked decrease in GABA synthesis after global ischemia [14, 17].
Negative_regulation (decrease) of Gene_expression (synthesis) of GABA in striatum associated with necrosis, gaba and ischemia
18) Confidence 0.16 Published 2010 Journal Cardiovascular Psychiatry and Neurology Section Body Doc Link PMC2957857 Disease Relevance 0.67 Pain Relevance 0.93
GABA microinjection into the RVLM in CRF decreased MAP (from 150 ± 5 to 86 ± 8?
Negative_regulation (decreased) of Gene_expression (microinjection) of GABA associated with gaba and chronic renal failure
19) Confidence 0.14 Published 2010 Journal International Journal of Hypertension Section Body Doc Link PMC3022169 Disease Relevance 0.71 Pain Relevance 0.41
Modafinil does not appear to have much effect on GABA in the thalamus or hippocampus, but GABA levels were reduced by modafinil in most brain regions studied: the cortex, medial preoptic area of the hypothalamus, posterior hypothalamus, nucleus accumbens, pallidum, and striatum, and this effect generally appears to be mediated by serotonin (Tanganelli et al 1995; Ferraro et al 1996, 1997a, b, 1998a, b, 1999).
Negative_regulation (reduced) of Gene_expression (levels) of GABA in medial associated with nucleus accumbens, gaba, urological neuroanatomy, hippocampus, thalamus and serotonin
20) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2654794 Disease Relevance 0.10 Pain Relevance 0.96

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