INT3188

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Context Info
Confidence 0.59
First Reported 1978
Last Reported 2010
Negated 26
Speculated 17
Reported most in Abstract
Documents 84
Total Number 101
Disease Relevance 8.94
Pain Relevance 38.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Acot1) mitochondrion (Acot1) lipid metabolic process (Acot1)
cytoplasm (Acot1)
Anatomy Link Frequency
striatum 22
hippocampus 14
cortex 12
cholinergic neurons 10
brain 9
Acot1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 123 100.00 Very High Very High Very High
tetrodotoxin 82 100.00 Very High Very High Very High
agonist 75 100.00 Very High Very High Very High
Morphine 68 100.00 Very High Very High Very High
Dopamine 58 100.00 Very High Very High Very High
Pain 14 100.00 Very High Very High Very High
Catecholamine 12 100.00 Very High Very High Very High
fluoxetine 10 100.00 Very High Very High Very High
Serotonin 9 100.00 Very High Very High Very High
ketamine 8 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Porphyria 16 100.00 Very High Very High Very High
Pain 10 100.00 Very High Very High Very High
Nociception 3 99.72 Very High Very High Very High
Overactive Bladder 4 99.56 Very High Very High Very High
Shock 6 99.48 Very High Very High Very High
Depression 27 99.02 Very High Very High Very High
Multiple System Atrophy 16 97.84 Very High Very High Very High
Ganglion Cysts 4 97.44 Very High Very High Very High
Urological Neuroanatomy 34 95.56 Very High Very High Very High
Brain Injury 6 93.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The selective micro-opiate agonist, [D-Ala(2),N-Me-Phe(4),Gly(5)-ol]-enkephalin (1 microM, coapplied with NMDA), was without effect on the NMDA-evoked release of ACh but abolished both dopamine-dependent (morning) and dopamine-independent (afternoon) responses of beta-funaltrexamine (10 nM and 1 microM).Therefore, in the limbic territory of the striatum enriched in striosomes, the micro-opioid-inhibitory regulation of ACh release follows diurnal rhythms.
Regulation (regulation) of Localization (release) of ACh in striatum associated with dopamine, agonist, enkephalin, opiate and opioid
1) Confidence 0.59 Published 2004 Journal Neuroscience Section Abstract Doc Link 14706785 Disease Relevance 0 Pain Relevance 0.73
The results suggest that in the rat hippocampus, both SS-28 and SS-14 interact with SS receptors to regulate ACh release indirectly by a mechanism that involves alterations of calcium influx during depolarization.
Regulation (regulate) of Localization (release) of ACh in hippocampus associated with somatostatin and hippocampus
2) Confidence 0.32 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 1976754 Disease Relevance 0 Pain Relevance 1.09
Moreover, oxotremorine, but not pilocarpine, inhibited ACh release in a concentration-dependent manner in either basal- or picric acid-evoked conditions, indicating the presence of muscarinic M2-receptors for auto-regulation of ACh release.
Regulation (auto-regulation) of Localization (release) of ACh
3) Confidence 0.27 Published 1986 Journal Neurosci. Lett. Section Abstract Doc Link 2875422 Disease Relevance 0 Pain Relevance 0.23
However, a lower dose of morphine (5 mg/kg, i.p.) did not affect ACh release in the striatum.
Neg (not) Regulation (affect) of Localization (release) of ACh in striatum associated with morphine
4) Confidence 0.27 Published 1993 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8095326 Disease Relevance 0 Pain Relevance 0.76
AIMS: The present study investigated the effects of ovariectomy and estrogen replacement on the release of acetylcholine (Ach) from cholinergic neurons as well as on the tetrodotoxin (TTX)-insensitive stretch-induced Ach release in isolated rat detrusor.
Spec (investigated) Regulation (effects) of Localization (release) of Ach in cholinergic neurons associated with tetrodotoxin and overactive bladder
5) Confidence 0.27 Published 2007 Journal Neurourol. Urodyn. Section Abstract Doc Link 17480029 Disease Relevance 0.10 Pain Relevance 0.10
In vivo microdialysis was used to assess the effects of novelty and pain on hippocampal ACh release in male and female rats.
Regulation (effects) of Localization (release) of ACh associated with pain
6) Confidence 0.24 Published 1999 Journal Brain Res. Section Abstract Doc Link 9878722 Disease Relevance 0.17 Pain Relevance 0.21
Formalin treatment decreased ACh release only in animals considered 'Inactive' during the Novelty phase while no modification in ACh release was observed in the 'Active' ones.
Neg (no) Regulation (modification) of Localization (release) of ACh
7) Confidence 0.24 Published 1997 Journal Brain Res. Section Abstract Doc Link 9067465 Disease Relevance 0.29 Pain Relevance 0.23
Effect of cyclic nucleotide derivatives on the release of ACh from cortical slices of the rat brain.
Regulation (Effect) of Localization (release) of ACh in brain
8) Confidence 0.24 Published 1980 Journal Brain Res. Section Title Doc Link 6243230 Disease Relevance 0 Pain Relevance 0.09
We examined the effect of morphine on the release of ACh in the RVLM of freely moving rats using the in vivo microdialysis method.
Spec (examined) Regulation (effect) of Localization (release) of ACh in RVLM associated with rostral ventrolateral medulla and morphine
9) Confidence 0.24 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10336550 Disease Relevance 0 Pain Relevance 0.81
However, propranolol (0.2 mg/kg, i.p.) did not affect the morphine-induced ACh release.
Neg (not) Regulation (affect) of Localization (release) of ACh associated with morphine
10) Confidence 0.24 Published 2003 Journal Biol. Pharm. Bull. Section Abstract Doc Link 14600399 Disease Relevance 0 Pain Relevance 1.06
The regulation of acetylcholine (ACh) release from cholinergic neurons transplanted to the hippocampus or neocortex was studied by microdialysis in awake rats.
Regulation (regulation) of Localization (release) of ACh in cholinergic neurons associated with hippocampus
11) Confidence 0.24 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239294 Disease Relevance 0.19 Pain Relevance 0.19
In conclusion, the graft-derived ACh release was affected by behavioral manipulations and catecholaminergic drugs that normally modify cholinergic septo-hippocampal and basalo-cortical activity.
Regulation (affected) of Localization (release) of ACh
12) Confidence 0.24 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239294 Disease Relevance 0.20 Pain Relevance 0.29
Since the activity of the normal basal forebrain projection systems is under influence of monoaminergic brainstem afferents, we investigated the effects of systemic administration of amphetamine or apomorphine on ACh release in the hippocampus.
Spec (investigated) Regulation (effects) of Localization (release) of ACh in brainstem associated with medulla, hippocampus and monoamine
13) Confidence 0.24 Published 1993 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 8239294 Disease Relevance 0.29 Pain Relevance 0.35
In the present study it was hypothesized that systemically administered muscarinic agonists and antagonists modify nociceptive threshold by affecting intraspinal release of acetylcholine (ACh).
Regulation (affecting) of Localization (release) of ACh associated with nociception, antagonist and agonist
14) Confidence 0.24 Published 2002 Journal Pharmacol. Toxicol. Section Abstract Doc Link 12076312 Disease Relevance 0.27 Pain Relevance 0.53
CONCLUSION: Ketamine produced more pronounced facilitatory effects on the hippocampal ACh release in old rats, as compared with young rats.
Regulation (effects) of Localization (release) of ACh
15) Confidence 0.24 Published 2000 Journal Acta Anaesthesiol Scand Section Body Doc Link 10669282 Disease Relevance 0 Pain Relevance 0
The present results indicate that lemon essential oil affects the ACh release differently in male and female rats during a painful condition.
Regulation (affects) of Localization (release) of ACh associated with pain
16) Confidence 0.24 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 12213626 Disease Relevance 0.27 Pain Relevance 0.36
Here we studied the effects of 6R-BH4 on acetylcholine (ACh) release in the rat hippocampus using brain microdialysis.
Regulation (effects) of Localization (release) of ACh in brain associated with hippocampus
17) Confidence 0.24 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1922955 Disease Relevance 0 Pain Relevance 0.36
The results show that control values for ACh release as well as the effect of morphine on neocortical ACh output were similar in both groups of rats.
Regulation (values) of Localization (release) of ACh associated with morphine
18) Confidence 0.24 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 7151877 Disease Relevance 0 Pain Relevance 0.32
Neither methylxanthines nor calcium modified the spontaneous release of ACh in the absence of morphine.
Neg (Neither) Regulation (modified) of Localization (release) of ACh associated with morphine
19) Confidence 0.24 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 658146 Disease Relevance 0 Pain Relevance 0.58
Theophylline antagonism of morphine action was dose related and this agent failed to influence a comparable action of chlorpromazine on the release of ACh.
Neg (failed) Regulation (influence) of Localization (release) of ACh associated with morphine
20) Confidence 0.24 Published 1978 Journal Eur. J. Pharmacol. Section Abstract Doc Link 658146 Disease Relevance 0 Pain Relevance 0.57

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