INT318819

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Context Info
Confidence 0.33
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.94
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1) extracellular space (IGF1) extracellular region (IGF1)
Anatomy Link Frequency
chondrocytes 2
IGF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 54 86.48 High High
imagery 18 40.16 Quite Low
Inflammation 6 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
vincristine 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Bile 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alveolar Rhabdomyosarcoma 40 99.90 Very High Very High Very High
Overweight 13 98.36 Very High Very High Very High
Hyperplasia 2 97.20 Very High Very High Very High
Cancer 20 91.56 High High
Metastasis 72 90.48 High High
Obesity 104 86.96 High High
Osteoarthritis 54 86.48 High High
Sarcoma 3 56.56 Quite High
Necrosis 1 33.24 Quite Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has also been reported that the PAX/FKHR fusion protein characteristic of alveolar RMS may induce transcription of IGF-I and other growth factors, further suggesting autocrine mechanisms of cellular proliferation [18, 19].
Spec (may) Positive_regulation (induce) of Transcription (transcription) of IGF-I associated with hyperplasia and alveolar rhabdomyosarcoma
1) Confidence 0.33 Published 2010 Journal Pediatr Radiol Section Body Doc Link PMC2895865 Disease Relevance 1.22 Pain Relevance 0
The adipokine at 100 ng/ml increased the mRNA level of IGF-1 in chondrocytes obtained from normal or overweight patients (Figure 2).
Positive_regulation (increased) of Transcription (level) of IGF-1 in chondrocytes associated with overweight
2) Confidence 0.22 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911905 Disease Relevance 0.73 Pain Relevance 0.07

General Comments

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