INT318926

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Context Info
Confidence 0.19
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.58
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (XIAP) intracellular (XIAP) ligase activity (XIAP)
cytoplasm (XIAP)
XIAP (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 2 38.36 Quite Low
Bile 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 22 98.84 Very High Very High Very High
Hepatolenticular Degeneration 70 93.00 High High
Targeted Disruption 4 60.88 Quite High
Dystonia 8 59.88 Quite High
Death 4 50.00 Quite Low
Pain 2 38.36 Quite Low
Dyskinesias 2 36.04 Quite Low
Intellectual Impairment 2 32.40 Quite Low
Sialorrhea 2 13.64 Low Low
Disease 16 6.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been reported that high copper accumulation increases XIAP-Cu interaction, eventually leading to degradation of XIAP [22].
Protein_catabolism (degradation) of XIAP
1) Confidence 0.19 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2896338 Disease Relevance 0.77 Pain Relevance 0
Based on these reports we speculate that the putative mutation (Thr174Met) in COMMD1 caused increased copper accumulation and hence degradation of XIAP which in turn decreased the apoptotic threshold in the patient, upregulating Caspase-3 mediated apoptosis.
Protein_catabolism (degradation) of XIAP associated with apoptosis
2) Confidence 0.19 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2896338 Disease Relevance 0.81 Pain Relevance 0

General Comments

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