INT318963

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 1.78
Pain Relevance 1.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
neurons 2
cortex 2
hypothalamus 1
amygdala 1
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 380 99.68 Very High Very High Very High
midbrain 18 94.48 High High
Thalamus 4 93.60 High High
Eae 12 51.44 Quite High
tetrodotoxin 4 15.80 Low Low
sodium channel 4 14.96 Low Low
interneuron 8 5.00 Very Low Very Low Very Low
long-term potentiation 6 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 97.40 Very High Very High Very High
Retts Disease 252 94.16 High High
Body Weight 18 94.12 High High
Anxiety Disorder 80 93.52 High High
Aids-related Complex 12 74.24 Quite High
Disease 34 67.92 Quite High
Tremor 12 18.76 Low Low
Cognitive Disorder 14 6.96 Low Low
Autism 22 5.00 Very Low Very Low Very Low
Targeted Disruption 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To substantiate the home cage observation that Mecp2?
Positive_regulation (observation) of Mecp2
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.09 Pain Relevance 0.03
Surprisingly, we found that expression of postsynaptic density-95 (PSD95) and synaptophysin (Syp) was significantly downregulated in hypothalamus of Mecp2?
Positive_regulation (hypothalamus) of Mecp2 in hypothalamus
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.16 Pain Relevance 0
One possible explanation is a presynaptic effect of Mecp2 thus pushing towards a role of Mecp2 in the cortex.
Positive_regulation (effect) of Mecp2 in cortex
3) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.30
Then another important question comes: Is the amygdala defect presented reflects an essential role of Mecp2 in the LA or a secondary consequence of a dysfunction of neurons projecting to the LA?
Positive_regulation (role) of Mecp2 in neurons associated with amygdala
4) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.35
One possible explanation is a presynaptic effect of Mecp2 thus pushing towards a role of Mecp2 in the cortex.
Positive_regulation (role) of Mecp2 in cortex
5) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.29
In fact, we [30] and Giacometti et al. [29] demonstrated that postnatal reactivation of MeCP2 in mutant animals is not sufficient to rescue the complete null phenotype unless MeCP2 levels are restored to the expected wild-type levels and done so in a sufficient number of neurons.
Positive_regulation (restored) of MeCP2 in neurons
6) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.47 Pain Relevance 0.03
Thus, our data strongly support the notion that Mecp2 is dispensable for synaptogenesis and synaptic function in the young mouse amygdala.
Positive_regulation (dispensable) of Mecp2 in amygdala associated with amygdala
7) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.40
/y-SC mice (figure 4A), suggesting that the restoration of a normal behavior on the plus maze induced by EE in Mecp2?
Positive_regulation (induced) of Mecp2
8) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.40 Pain Relevance 0
Thus we propose that EE restores MeCP2 mutant's ability to appropriately perceive environmental clues.
Positive_regulation (restores) of MeCP2
9) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.60 Pain Relevance 0
It is also notable that in spite of an observable EE-induced motor improvement in Mecp2?
Positive_regulation (induced) of Mecp2
10) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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