INT318967

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Context Info
Confidence 0.77
First Reported 2010
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 9
Total Number 31
Disease Relevance 11.52
Pain Relevance 3.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Anatomy Link Frequency
synapses 5
brains 3
neurons 2
neuronal 1
cortex 1
Mecp2 (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 855 100.00 Very High Very High Very High
midbrain 66 86.48 High High
long-term potentiation 22 85.36 High High
anesthesia 22 79.64 Quite High
tetrodotoxin 9 69.00 Quite High
sodium channel 9 68.16 Quite High
Hippocampus 9 67.52 Quite High
Eae 44 39.04 Quite Low
GABAergic 9 20.40 Low Low
Neurotransmitter 9 8.12 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 248 100.00 Very High Very High Very High
Body Weight 66 100.00 Very High Very High Very High
Targeted Disruption 53 100.00 Very High Very High Very High
Retts Disease 856 99.64 Very High Very High Very High
Disease 119 94.24 High High
Tremor 44 94.08 High High
Autism 75 94.04 High High
Stress 66 93.76 High High
Congenital Anomalies 22 93.28 High High
Sprains And Strains 31 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This process is amplified by the absence of Mecp2, but with a preserved timing (Fig. 2).
Neg (absence) Gene_expression (absence) of Mecp2
1) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.55 Pain Relevance 0.16
Synaptic maturation and elimination at excitatory projections to the LA in Mecp2 deficient mice
Gene_expression (deficient) of Mecp2 associated with amygdala
2) Confidence 0.77 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.70
Additional support for this idea came from experiments in which the phenotypes of the Mecp2 null mice were rescued by neuronal expression of transgenic Mecp2 [8].
Gene_expression (expression) of Mecp2 in neuronal associated with targeted disruption
3) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 1.16 Pain Relevance 0.11
We studied the effects of environmental enrichment (EE) on the phenotypic manifestations of a RTT mouse model that lacks MeCP2 (Mecp2?
Neg (lacks) Gene_expression (lacks) of MeCP2 associated with retts disease
4) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2902516 Disease Relevance 0.88 Pain Relevance 0
It was visually evident that the movements of Mecp2?
Gene_expression (movements) of Mecp2
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.36 Pain Relevance 0
The steady state level of PSD95 and Syp mRNAs in Mecp2?
Gene_expression (mRNAs) of Mecp2
6) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.17 Pain Relevance 0
/y mice to what was expected based on previous studies of EE transcriptional effects with respect to synaptophysin, syntaxin 1a and synaptotagmin, we also did not detect changes in gene expression of genes shown to respond to EE such as IGF-I, IGFbp, BDNF, Grin2B, Gria, Gap43, Nefm, Dyn1 and N-Cadh in brains of Mecp2?
Gene_expression (brains) of Mecp2 in brains
7) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.06 Pain Relevance 0.08
However, if the Mecp2?
Gene_expression (if) of Mecp2
8) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.36 Pain Relevance 0
The mice we used were male mice (dubbed Mecp2?
Gene_expression (dubbed) of Mecp2
9) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.68 Pain Relevance 0
Because of this, we were able to notice that Mecp2?
Gene_expression (notice) of Mecp2
10) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.38 Pain Relevance 0
We found that EE delayed and attenuated some neurological alterations presented by Mecp2?
Gene_expression (presented) of Mecp2
11) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2902516 Disease Relevance 0.86 Pain Relevance 0
However, the Mecp2?
Gene_expression (However) of Mecp2
12) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.38 Pain Relevance 0
Conditional deletion of Mecp2 in either embryonic or postmitotic neurons results in a phenotype similar to complete knockout [5], [6], suggesting that RTT is caused by dysfunction of brain neurons.
Gene_expression (deletion) of Mecp2 in brain associated with targeted disruption and retts disease
13) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 1.34 Pain Relevance 0.11
We thus compared the expression of synaptic markers in Mecp2-null mice subjected to EE or SC.
Gene_expression (expression) of Mecp2-null
14) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.46 Pain Relevance 0
We studied the effects of environmental enrichment (EE) on the phenotypic manifestations of a RTT mouse model that lacks MeCP2 (Mecp2?
Neg (lacks) Gene_expression (lacks) of Mecp2 associated with retts disease
15) Confidence 0.68 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2902516 Disease Relevance 0.88 Pain Relevance 0
/y-EE mice was not detectable at 4 weeks of age (levels of severity 0) but started at 5 weeks following the same course of the Mecp2?
Gene_expression (course) of Mecp2
16) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.12 Pain Relevance 0
Further, we observed that the behavior of the Mecp2?
Gene_expression (behavior) of Mecp2
17) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.36 Pain Relevance 0
Interestingly, analysis of candidate gene expression in the cortex showed that Mecp2?
Gene_expression (showed) of Mecp2 in cortex
18) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902516 Disease Relevance 0.14 Pain Relevance 0
Importantly, at each tested post natal age the absence of Mecp2 never impacts associative presynaptic LTP (KO Adult: 147±15% of baseline, p>0.05 as compared to WT adult, and p<0.05 as compared to baseline, Fig. 3) suggesting that the increase in release probability at Mecp2 deficient adult Cortico-LA synapses may not be linked to an over-activation of the cAMP/PKA/Rim pathway [38].
Gene_expression (synapses) of Mecp2 in synapses associated with amygdala
19) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.08 Pain Relevance 0.21
One intriguing question is the effect of age and of Mecp2 deletion onto Cortico-LA but not Thalamo-LA synapses.
Gene_expression (deletion) of Mecp2 in synapses associated with amygdala
20) Confidence 0.67 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.05 Pain Relevance 0.26

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