INT318968

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Context Info
Confidence 0.22
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pth1r) plasma membrane (Pth1r) nucleus (Pth1r)
intracellular (Pth1r) cytoplasm (Pth1r) signal transducer activity (Pth1r)
Anatomy Link Frequency
synapses 1
Pth1r (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 95 100.00 Very High Very High Very High
interneuron 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Hippocampus 1 5.00 Very Low Very Low Very Low
GABAergic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 8 23.68 Low Low
Retts Disease 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low
Autism 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the strong decrease in Cortico-LA PPR in adult Mecp2308/Y mice (Fig. 2), we conclude that the prolonged absence of Mecp2 strongly increased release probability at Cortico-LA synapses, possibly compensating for the progressive synaptic elimination.


Negative_regulation (decrease) of PPR in synapses associated with amygdala
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0 Pain Relevance 0.47

General Comments

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