INT318969

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.28
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Mecp2) embryo development (Mecp2) DNA binding (Mecp2)
protein complex (Mecp2) response to stress (Mecp2) cytoplasm (Mecp2)
Mecp2 (Mus musculus)
Bdnf (Mus musculus)
Pain Link Frequency Relevance Heat
amygdala 95 88.00 High High
Hippocampus 1 38.16 Quite Low
interneuron 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
GABAergic 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retts Disease 12 86.64 High High
Autism 1 63.64 Quite High
Anxiety Disorder 8 50.00 Quite Low
Targeted Disruption 1 42.32 Quite Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Intellectual Impairment 1 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also, associative LTP is not systematically affected in Mecp2 deficient preparations [10]–[12], but when defective, is rescued by reintroduction of Mecp2 [13] suggesting that the presence of Mecp2 in the adult is important to maintain synaptic function, possibly due to the activity-dependent control of BDNF production by Mecp2 [14], [15].
Mecp2 Regulation (control) of Gene_expression (production) of BDNF
1) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2896423 Disease Relevance 0.28 Pain Relevance 0.17

General Comments

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