INT319021

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.44
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Angina 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nicotine Addiction 30 99.86 Very High Very High Very High
Coronary Artery Disease 42 98.48 Very High Very High Very High
Disease 4 76.52 Quite High
Atherosclerosis 12 76.20 Quite High
Apoptosis 3 63.68 Quite High
Necrosis 1 62.32 Quite High
Stress 2 51.92 Quite High
Obesity 8 43.52 Quite Low
Hypertension 7 42.16 Quite Low
Diabetes Mellitus 9 40.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Smoking might lower NPC1 transcription, by somehow disrupting the binding of transcription factors, therefore, leading to intracellular cholesterol accumulation.
Spec (might) Negative_regulation (lower) of Transcription (transcription) of NPC1 associated with nicotine addiction
1) Confidence 0.38 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2966454 Disease Relevance 1.44 Pain Relevance 0
It has been demonstrated that following intramuscular injection of D-SPM/pDNA, the highest level of gene expression was observed with 50??
Negative_regulation (following) of Transcription (injection) of D-SPM/pDNA
2) Confidence 0.15 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0 Pain Relevance 0

General Comments

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