INT319022

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Context Info
Confidence 0.50
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.24
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Npc1) nuclear envelope (Npc1) Golgi apparatus (Npc1)
endoplasmic reticulum (Npc1) plasma membrane (Npc1) lysosome (Npc1)
Npc1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1 60.12 Quite High
cytokine 1 25.52 Quite Low
Inflammation 2 24.76 Low Low
imagery 3 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
antiepileptic Drug 1 5.00 Very Low Very Low Very Low
peripheral neuropathy 1 5.00 Very Low Very Low Very Low
medulla 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Emphysema 1 61.04 Quite High
Asthma 1 60.44 Quite High
Cystic Fibrosis 1 60.12 Quite High
Pulmonary Disease 2 57.80 Quite High
Pick Disease Of The Brain 12 50.00 Quite Low
Cytomegalovirus Infection 4 44.48 Quite Low
INFLAMMATION 3 24.76 Low Low
Disease 109 23.24 Low Low
Neurodegenerative Disease 2 22.72 Low Low
Congenital Anomalies 11 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Binding of cholesterol to NPC1 and dissociation both appear accelerated by NPC2 [83].
Spec (appear) Positive_regulation (accelerated) of NPC1 Binding (Binding) of
1) Confidence 0.50 Published 2010 Journal Orphanet J Rare Dis Section Body Doc Link PMC2902432 Disease Relevance 0 Pain Relevance 0
Accumulation of the aggregates of D-SPM/pDNA and serum protein could entrap the pDNA inside the complex by impeding the disassociation of the pDNA from the D-SPM, after its uptake into the cells' cytoplasm.
Positive_regulation (Accumulation) of D-SPM/pDNA Binding (aggregates) of
2) Confidence 0.17 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896664 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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