INT31905
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Differentiation with retinoic acid increases the levels of opioid receptor binding in the cell line, with the largest elevations in kappa 3 binding. | |||||||||||||||
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Enhanced binding of morphine and nalorphine to opioid delta receptor by glucuronate and sulfate conjugations at the 6-position. | |||||||||||||||
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Structural requirements for dermorphin opioid receptor binding. | |||||||||||||||
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Naltrexone disrupts this feedback control by reducing micro opioid receptor function, thereby up-regulating delta opioid receptor binding, which results in an enhanced NK cell cytolytic response to delta opioid receptor ligands. | |||||||||||||||
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These results indicate that cocaine-induced turning and its potentiation by mu-opioid receptor agonists are dependent upon the inhibition of dopamine reuptake. | |||||||||||||||
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The effects of maptazinol however only recovered after 72 hr, suggesting that antagonism by naloxonazine of this ligand was irreversible and was mediated through a unique opioid receptor interaction. | |||||||||||||||
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Chronic opioid antagonist administration upregulates mu opioid receptor binding without altering mu opioid receptor mRNA levels. | |||||||||||||||
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In contrast, a highly specific decrease in kappa(2)-, but increase in kappa(1)-, opioid receptor binding was noted in the hippocampus of rats in both butorphanol-dependent and-withdrawal groups. | |||||||||||||||
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Other interactions between progesterone and neurotransmitter systems include stimulation of dopamine release in striatal tissue, stimulation of GnRH release from hypothalamic neurons and inhibition of opioid receptor binding and activation. | |||||||||||||||
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Further studies revealed agonist-selective differences in the ability to induce opioid receptor internalization. | |||||||||||||||
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CONCLUSIONS: This study suggests that opioid receptor binding is increased throughout the brain in early abstinence from dependent opioid use. | |||||||||||||||
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Upregulation of opioid receptor binding following spontaneous epileptic seizures. | |||||||||||||||
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These studies demonstrate an involvement of the NMDA receptor in the development of kappa-opioid tolerance and suggest that the biochemical consequences of an opioid's interaction with the opioid receptor are not the only factors that contribute to the acute and chronic actions of opioid analgesic drugs. | |||||||||||||||
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In a variety of species including mouse, rat, guinea pig and human, opioid levels and opioid receptor concentration fluctuate during development [11, 316]: universal opioid receptor binding is high during early embryogenesis, decreases towards birth, then gradually increases to adult levels [12, 22, 316]. | |||||||||||||||
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Hence, it is suggested that melatonin exerts its analgesic actions not by binding to opioid receptor subtypes but by binding to its own receptors and increasing the release of beta-endorphin. | |||||||||||||||
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In general, high levels of opioid receptor binding was seen in the cortical projections of the medial pain system (cingulate and frontal cortex) and a focal lower binding was observed in the primary sensorimotor cortex, a part of the lateral pain system. | |||||||||||||||
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The results of these studies define specific structural features of these compounds responsible for opioid receptor interactions and suggest a possibly novel mechanism for delta receptor activation. | |||||||||||||||
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The continuous activation of the opioid receptor associated with the development of dependence may induce changes in Ni which in turn prevent the interaction of IAP with its substrate. | |||||||||||||||
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The percent increase of opioid receptor binding in KO mice is between 7.8 and 18% in the ACC [30]. | |||||||||||||||
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Structural requirements for delta opioid receptor binding. | |||||||||||||||
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General Comments
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