INT31911

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Context Info
Confidence 0.19
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 2.16
Pain Relevance 6.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein targeting (Hps4) cytoplasmic membrane-bounded vesicle (Hps4) lysosome (Hps4)
cytoplasm (Hps4)
Anatomy Link Frequency
hippocampal formation 1
spinal cord 1
hilus 1
synapses 1
Hps4 (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 58 100.00 Very High Very High Very High
mu opioid receptor 29 99.90 Very High Very High Very High
Inflammation 41 99.52 Very High Very High Very High
Opioid 3 99.26 Very High Very High Very High
Spinal cord 8 98.92 Very High Very High Very High
Arthritis 53 98.08 Very High Very High Very High
Analgesic 2 97.02 Very High Very High Very High
Dorsal horn 7 96.12 Very High Very High Very High
Dynorphin 6 91.12 High High
rheumatoid arthritis 16 89.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 41 99.52 Very High Very High Very High
Disease 2 99.00 Very High Very High Very High
Arthritis 59 98.08 Very High Very High Very High
Pressure And Volume Under Development 16 92.04 High High
Rheumatoid Arthritis 16 89.76 High High
Hyperalgesia 2 75.76 Quite High
Pain 2 75.00 Quite High
Hypertrophy 1 50.08 Quite High
Diabetes Mellitus 1 39.40 Quite Low
Hypersensitivity 4 38.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid peptides, including leu-enkephalin (LE), are important neuromodulators in the hippocampal formation where they may play a role in learning and memory as well as epileptogenesis.
Regulation (neuromodulators) of LE in hippocampal formation associated with enkephalin and opioid
1) Confidence 0.19 Published 1995 Journal J. Comp. Neurol. Section Abstract Doc Link 7560290 Disease Relevance 0 Pain Relevance 0.66
We further determined the effects of LE and rLE on chronic inflammatory diseases using a mouse CIA model.
Spec (determined) Regulation (effects) of rLE associated with inflammation, disease and arthritis
2) Confidence 0.04 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2841253 Disease Relevance 1.70 Pain Relevance 0.61
In contrast, few (3%) MOR-ir profiles contacted LE-ir profiles; only 16% of these contacts included observable synapses, and very few profiles (0.5%) colocalized MOR and LE immunoreactivity.
Regulation (immunoreactivity) of LE in synapses associated with enkephalin
3) Confidence 0.02 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12093103 Disease Relevance 0 Pain Relevance 1.53
To elucidate the relationships between potential sites of enkephalin release and MORs, MOR1 and leucine-enkephalin (LE) immunoreactivities were localized in the hilus by electron microscopy, using immunoperoxidase and immunogold markers.
Regulation (immunoreactivities) of LE in hilus associated with mu opioid receptor and enkephalin
4) Confidence 0.02 Published 2002 Journal Exp. Neurol. Section Abstract Doc Link 12093103 Disease Relevance 0 Pain Relevance 1.01
Furthermore, levels of ir-met-enkephalin (ME) and ir-leu-enkephalin (LE) were unaffected.
Neg (unaffected) Regulation (unaffected) of LE associated with enkephalin
5) Confidence 0.02 Published 1988 Journal Pain Section Abstract Doc Link 2906425 Disease Relevance 0.47 Pain Relevance 1.50
To establish the cellular sites for the spinally mediated analgesic effects of MOR activation and the potential anatomical substrates for interactions with LE, we examined the ultrastructural localization of MOR and LE immunoreactivities in the adult rat cervical spinal cord (C3-C5).
Spec (examined) Regulation (immunoreactivities) of LE in spinal cord associated with analgesic, mu opioid receptor, enkephalin and spinal cord
6) Confidence 0.01 Published 1996 Journal Brain Res. Section Abstract Doc Link 8883864 Disease Relevance 0 Pain Relevance 1.51

General Comments

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