INT31912

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Context Info
Confidence 0.25
First Reported 1984
Last Reported 2001
Negated 2
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.93
Pain Relevance 3.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (OPRD1) cytoplasm (OPRD1) signal transducer activity (OPRD1)
OPRD1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 21 100.00 Very High Very High Very High
opioid receptor 3 100.00 Very High Very High Very High
antagonist 3 100.00 Very High Very High Very High
Inflammation 7 98.56 Very High Very High Very High
Enkephalin 9 97.72 Very High Very High Very High
Dynorphin 9 97.48 Very High Very High Very High
Morphine 1 96.68 Very High Very High Very High
analgesia 3 94.12 High High
Thermal hyperalgesia 2 94.00 High High
Opioid 3 87.40 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 6 98.56 Very High Very High Very High
Hyperalgesia 3 94.00 High High
Pressure And Volume Under Development 1 90.76 High High
Nociception 1 82.88 Quite High
Tics 1 52.72 Quite High
Bordatella Infection 1 49.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This study assessed the effects of short-term treatment (30-min) with inverse agonists on receptor protein levels and on the ability of agonists, inverse agonists, and neutral antagonists to bind to the human delta-opioid receptor (h delta OR).
Regulation (effects) of delta-opioid receptor Binding (bind) of associated with antagonist, agonist and opioid receptor
1) Confidence 0.25 Published 2001 Journal Mol. Pharmacol. Section Abstract Doc Link 11562445 Disease Relevance 0.05 Pain Relevance 0.71
No alteration of kappa, mu or delta receptor binding was observed at 4 h or 4 days post inflammation.
Neg (No) Regulation (alteration) of delta receptor Binding (binding) of associated with inflammation
2) Confidence 0.01 Published 1988 Journal Pain Section Abstract Doc Link 2906426 Disease Relevance 0.88 Pain Relevance 1.07
This suggested that in the hot plate test, there is no modulation of the effect resulting from mu-receptor stimulation by a delta-receptor interaction.
Neg (no) Regulation (modulation) of delta-receptor Binding (interaction) of
3) Confidence 0.00 Published 1984 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6086366 Disease Relevance 0 Pain Relevance 1.33

General Comments

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