INT319133

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Context Info
Confidence 0.02
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 0.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ahrr) nucleus (Ahrr) DNA binding (Ahrr)
cytoplasm (Ahrr) signal transducer activity (Ahrr)
Anatomy Link Frequency
nucleus 1
Ahrr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 17 59.72 Quite High
agonist 17 49.32 Quite Low
Angina 1 20.32 Low Low
Multiple sclerosis 3 5.00 Very Low Very Low Very Low
rheumatoid arthritis 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammatory stimuli 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 4 96.96 Very High Very High Very High
INFLAMMATION 20 59.72 Quite High
Cancer 3 55.48 Quite High
Reprotox - General 3 1 55.00 Quite High
Obesity 13 54.48 Quite High
Aging 1 54.12 Quite High
Pathologic Processes 1 52.32 Quite High
Fibrodysplasia Ossificans Progressiva 19 50.00 Quite Low
Pressure And Volume Under Development 3 41.64 Quite Low
Overweight 1 41.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The products of these genes interact to form repressor complexes which translocate into the nucleus and inhibit Bmal1-CLOCK/NPAS2 activity, thus resulting in repression of their own transcription [7].
Localization (translocate) of repressor in nucleus associated with repression
1) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.10 Pain Relevance 0
The simultaneous release of repressor cofactors and recruitment of coactivators also occur.
Localization (release) of repressor
2) Confidence 0.01 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.38 Pain Relevance 0.06

General Comments

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