INT319164

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Context Info
Confidence 0.42
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Kat2a) nucleus (Kat2a)
Anatomy Link Frequency
oocytes 6
embryos 2
Kat2a (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Polycystic Ovary Syndrome 12 79.80 Quite High
Ovarian Hyperstimulation Syndrome 8 78.12 Quite High
Dislocations 8 19.44 Low Low
Cancer 4 5.00 Very Low Very Low Very Low
Reprotox - General 3 4 5.00 Very Low Very Low Very Low
Immunotherapy Of Cancer 4 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, GCN5 protein expressions were decreased in IVM oocytes and two-cell embryos.
Negative_regulation (decreased) of Gene_expression (expressions) of GCN5 in oocytes
1) Confidence 0.42 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
Results showed that IVM downregulated the protein expression of GCN5 in MII oocytes and two-cell embryos and changed the distribution of GCN5 in two-cell embryos.
Negative_regulation (downregulated) of Gene_expression (expression) of GCN5 in embryos
2) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Abstract Doc Link PMC2896857 Disease Relevance 0.24 Pain Relevance 0
The decreased expression and altered distribution of GCN5 in IVM oocytes and two-cell embryos suggested that IVM could disturb the function of GCN5 during the period of reprogramming, which might lead to epigenetic alterations.
Negative_regulation (decreased) of Gene_expression (expression) of GCN5 in oocytes
3) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0
We determined the expression and distribution of GCN5, HDAC1, and Ac-H3 in metaphase II oocytes matured in vitro and in vivo.
Spec (determined) Negative_regulation (determined) of Spec (determined) Gene_expression (expression) of GCN5 in oocytes
4) Confidence 0.31 Published 2010 Journal Obstetrics and Gynecology International Section Body Doc Link PMC2896857 Disease Relevance 0 Pain Relevance 0

General Comments

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