INT319182

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Context Info
Confidence 0.46
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.95
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SOD2) oxidoreductase activity (SOD2) aging (SOD2)
mitochondrion organization (SOD2) DNA binding (SOD2) cytoplasm (SOD2)
Anatomy Link Frequency
SH-SY5Y 2
SOD2 (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 80 99.98 Very High Very High Very High
cINOD 9 36.68 Quite Low
Immobilon 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 10 99.30 Very High Very High Very High
Apoptosis 44 96.04 Very High Very High Very High
Necrosis 2 92.88 High High
Cancer 3 92.52 High High
Stress 4 72.24 Quite High
Parkinson's Disease 4 60.52 Quite High
Injury 4 48.56 Quite Low
Nephrotoxicity 1 46.56 Quite Low
INFLAMMATION 2 9.08 Low Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our data show that the treatment of the neuroblastoma cell line SH-SY5Y with diclofenac induces a decrease in SOD2 protein level and an increase of the ROS concentration.
Positive_regulation (induces) of Negative_regulation (decrease) of SOD2 protein in SH-SY5Y associated with neuroblastoma and diclofenac
1) Confidence 0.46 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2896885 Disease Relevance 0.95 Pain Relevance 0.17

General Comments

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