INT31923

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Context Info
Confidence 0.44
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 1.88
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adra2a) plasma membrane (Adra2a) cytoplasm (Adra2a)
signal transducer activity (Adra2a)
Anatomy Link Frequency
myocytes 2
blood 2
nerve 2
neurons 2
locus coeruleus 2
Adra2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 14 100.00 Very High Very High Very High
tolerance 5 100.00 Very High Very High Very High
Analgesic 2 100.00 Very High Very High Very High
Pain 2 100.00 Very High Very High Very High
Locus ceruleus 5 99.68 Very High Very High Very High
Spinal cord 2 98.12 Very High Very High Very High
Serotonin 2 97.86 Very High Very High Very High
antagonist 4 97.56 Very High Very High Very High
agonist 33 97.28 Very High Very High Very High
analgesia 1 94.52 High High
Disease Link Frequency Relevance Heat
Hypoxia 10 100.00 Very High Very High Very High
Hypertension 2 98.64 Very High Very High Very High
Brain Injury 1 96.28 Very High Very High Very High
Nervous System Injury 1 88.20 High High
Heart Rate Under Development 1 86.20 High High
Cv Unclassified Under Development 25 81.48 Quite High
Hyperglycemia 2 81.44 Quite High
Htlv Types I And Ii 39 78.08 Quite High
Coronary Artery Disease 2 75.64 Quite High
Natriuresis 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous results from our laboratory have indicated that small intravenous doses of the alpha 2-adrenergic agonist clonidine increase serotonin (5-HT) neurotransmission by attenuating the release of endogenous norepinephrine (NE), as a result of the activation of alpha 2-adrenergic autoreceptor on NE neurons, and that high doses of clonidine decrease 5-HT neurotransmission by directly activating alpha 2-adrenergic heteroreceptors on 5-HT terminals.
Positive_regulation (activation) of Positive_regulation (activating) of 2-adrenergic in neurons associated with agonist, serotonin and clonidine
1) Confidence 0.44 Published 1994 Journal Neuropsychopharmacology Section Abstract Doc Link 8179793 Disease Relevance 0 Pain Relevance 0.50
alpha2-Adrenoceptor activation by clonidine enhances stimulation-evoked acetylcholine release from spinal cord tissue after nerve ligation in rats.
Positive_regulation (enhances) of Positive_regulation (activation) of alpha2-Adrenoceptor in nerve associated with analgesic, spinal cord and clonidine
2) Confidence 0.36 Published 2005 Journal Anesthesiology Section Title Doc Link 15731607 Disease Relevance 0.09 Pain Relevance 0.99
Chronic hypobaric hypoxia induces tolerance to acute hypoxia and up-regulation in alpha-2 adrenoceptor in rat locus coeruleus.
Positive_regulation (induces) of Positive_regulation (up-regulation) of alpha-2 adrenoceptor in locus coeruleus associated with hypoxia, locus ceruleus and tolerance
3) Confidence 0.36 Published 2006 Journal Brain Res. Section Title Doc Link 16842765 Disease Relevance 0.81 Pain Relevance 0.57
Combined alpha 1- and beta-adrenoceptor blockade resulted in an increase in the alpha 2-adrenoceptor-mediated hyperglycemic response to adrenaline.
Positive_regulation (resulted) of Positive_regulation (increase) of alpha 2-adrenoceptor-mediated
4) Confidence 0.35 Published 1988 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2906612 Disease Relevance 0.16 Pain Relevance 0.13
In contrast, the coronary vasodilatory effect of moxonidine requires full activation of alpha2-adrenoceptor.
Positive_regulation (requires) of Positive_regulation (activation) of alpha2-adrenoceptor
5) Confidence 0.16 Published 2006 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16774751 Disease Relevance 0.16 Pain Relevance 0.28
Activation of A2AAR can increase inotropy of the ventricular myocytes [14] and/or improve left ventricular function.
Positive_regulation (increase) of Positive_regulation (Activation) of A2AAR in myocytes
6) Confidence 0.07 Published 2009 Journal The Open Cardiovascular Medicine Journal Section Body Doc Link PMC2811859 Disease Relevance 0.56 Pain Relevance 0.41
RESULTS: Local activation of the I1 receptor by rilmenidine (40 nmol) or by the I1/alpha2 receptor mixed agonist clonidine (1 nmol), and local activation of the alpha2-adrenergic receptor (alpha2AR) by the pure alpha2AR agonist alpha-methylnorepinephrine (alpha-MNE, 10 nmol) caused reductions in RVLM NE, and blood pressure.
Positive_regulation (activation) of Positive_regulation (activation) of alpha2-adrenergic in blood
7) Confidence 0.05 Published 2007 Journal Alcohol. Clin. Exp. Res. Section Body Doc Link 17374048 Disease Relevance 0.10 Pain Relevance 0

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